Evidence map›Paper›PMID 32258231›Full record

ArticleMovement disorders clinical practice2020

Pseudoagoraphobia, a Diagnostic Clue in Stiff-Limb Syndrome.

Massimo Marano, Francesco Motolese, Jacopo Lanzone, Alessandro Di Santo, Mariagrazia Rossi, Maria Gabriela Bevacqua, Federico Ranieri, Fioravante Capone, Emilia Mabel Gatto, Vincenzo Di Lazzaro

Open access · greenAbstract readCase Reports
In one paragraph

Article in Movement disorders clinical practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Massimo MaranoNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine Università Campus Bio-Medico di Roma Rome Italy.ORCID https://orcid.org/0000-0001-9885-3666
Francesco MotoleseNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine Università Campus Bio-Medico di Roma Rome Italy.
Jacopo LanzoneNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine Università Campus Bio-Medico di Roma Rome Italy.
Alessandro Di SantoNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine Università Campus Bio-Medico di Roma Rome Italy.
Mariagrazia RossiNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine Università Campus Bio-Medico di Roma Rome Italy.
Maria Gabriela BevacquaPsychiatry, "Psyche" Neurosciences clinic Rome Italy.
Federico RanieriDepartment of Neuroscience, Biomedicine and Movement Sciences University of Verona Verona Italy.ORCID https://orcid.org/0000-0001-6530-1857
Fioravante CaponeNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine Università Campus Bio-Medico di Roma Rome Italy.
Emilia Mabel GattoDepartment of Neurology, Sanatorio de la Trinidad Mitre Buenos Aires University Buenos Aires Argentina.
Vincenzo Di LazzaroNeurology, Neurophysiology and Neurobiology Unit, Department of Medicine Università Campus Bio-Medico di Roma Rome Italy.
Università Campus Bio-Medico · ITHospital de Niños de la Santísima Trinidad · ARNeuroscience Institute · ITUniversity of Verona · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStiff-limb syndrome is part of stiff person spectrum, presenting with fluctuating gait disorders attributed to leg stiffness, spasms, and posturing. It could also manifest with anxiety and specific phobias such as pseudoagoraphobia. We aimed to describe the importance of specific gait phobia as a diagnostic clue to anti-glutamic acid decarboxylase stiff-limb syndrome. CASES: We reported on 2 cases of stiff-limb syndrome sharing a similar diagnostic path and phenomenology. Both were featured by pseudoagoraphobia, which has documented to typically cover organic conditions, and a remarkable diagnostic delay attributed to misdiagnoses. Presence of pseudoagoraphobia should not point to the diagnosis of a functional disorder-although a negative instrumental workup is documented.

conclusionsBoth cases are emblematic of the high misdiagnosis rate affecting stiff person syndrome patients. A proper diagnostic process, including the identification of a pseudoagoraphobia, should help in reaching a diagnosis and providing an early and effective treatment.

Indexed as

anti‐GAD antibodiesfunctional movement disordersgaitspasticitystiff man syndrome

Identifiers

PMID32258231
PMCPMC7111565
OpenAlexW3005614176

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.