Evidence map›Paper›PMID 32258172›Full record

ArticleJournal of immunology research2020

A 7-Amino Acid Peptide Mimic from Hepatitis C Virus Hypervariable Region 1 Inhibits Mouse Lung Th9 Cell Differentiation by Blocking CD81 Signaling during Allergic Lung Inflammation.

Wanzhou Zhao, Conghao Tan, Xi Yu, Ruihe Yu, Qibing Mei, Yun Cheng

Open access · goldAbstract read
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wanzhou ZhaoThe Nanjing Han & Zaenker Cancer Institute (NHZCI), OG Pharmaceuticals, Jiangdongbei Road 88, Nanjing, 210036 Jiangsu Province, China.
Conghao TanSchool of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013 Jiangsu Province, China.
Xi YuThe Nanjing Han & Zaenker Cancer Institute (NHZCI), OG Pharmaceuticals, Jiangdongbei Road 88, Nanjing, 210036 Jiangsu Province, China.
Ruihe YuThe Nanjing Han & Zaenker Cancer Institute (NHZCI), OG Pharmaceuticals, Jiangdongbei Road 88, Nanjing, 210036 Jiangsu Province, China.
Qibing MeiLuzhou New Drug Evaluation and Research Center, Luzhou, 646000 Sichuan Province, China.
Yun ChengThe Nanjing Han & Zaenker Cancer Institute (NHZCI), OG Pharmaceuticals, Jiangdongbei Road 88, Nanjing, 210036 Jiangsu Province, China.ORCID https://orcid.org/0000-0002-6357-7953
Jiangsu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

T helper (Th) cells orchestrate allergic lung inflammation in asthma pathogenesis. Th9 is a novel Th cell subset that mainly produces IL-9, a potent proinflammatory cytokine in asthma. A 7-amino acid peptide (7P) of the hypervariable region 1 (HVR1) of hepatitis C virus has been identified as an important regulator in the type 2 cytokine (IL-4, IL-5, and IL-13) immune response. However, it is unknown whether 7P regulates Th9 cell differentiation during ovalbumin- (OVA-) induced allergic lung inflammation. To address this, we studied wild-type mice treated with 7P and a control peptide in an

Indexed as

Amino Acid SequenceAnimalsAsthmaCell DifferentiationCells, CulturedHepacivirusHumansHypersensitivityInfusion Pumps, ImplantableInterleukin-9LungMaleMiceMice, Inbred C57BLMolecular MimicryPeptidesHVR1 protein, Hepatitis C virusInterleukin-9PeptidesTetraspanin 28Viral Proteins

Identifiers

PMID32258172
PMCPMC7109583
OpenAlexW3011793807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.