Evidence map›Paper›PMID 32258171›Full record

ArticleJournal of immunology research2020

Impact of IFN-Free and IFN-Based Treatment on Blood Myeloid Dendritic Cell, Monocyte, Slan-DC, and Activated T Lymphocyte Dynamics during HCV Infection.

Serena Vita, Paola Zuccalà, Stefano Savinelli, Claudia Mascia, Raffaella Rossi, Francesco Schiavone, Raffaella Marocco, Tiziana Tieghi, Marco Iannetta, Parni Nijhawan and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Serena VitaDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0002-2573-732X
Paola ZuccalàDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.
Stefano SavinelliDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.
Claudia MasciaDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.
Raffaella RossiDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.
Francesco SchiavoneDepartment of Molecular Medicine, Sapienza University of Rome, Italy.
Raffaella MaroccoS.M. Goretti Hospital, Latina, Italy.
Tiziana TieghiS.M. Goretti Hospital, Latina, Italy.
Marco IannettaDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.
Parni NijhawanDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.
Maria Antonella ZingaropoliDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.
Gabriella d'EttoreDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.
Vincenzo VulloDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.
Claudio Maria MastroianniDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0002-1286-467X
Miriam LichtnerDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Italy.ORCID https://orcid.org/0000-0002-7730-3953
Sapienza University of Rome · ITOspedale Santa Maria Goretti · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic hepatitis C virus infection leads to the activation of innate immunity, a key component in HCV fibrosis. In the past, the use of IFN-based treatment regimens did not permit an adequate evaluation of the impact of HCV clearance on immune cells, because of their antiviral and immunomodulatory properties. The recent development of direct-acting antiviral (DAA) therapy, which is associated with high rates of sustained virological response, enables a more accurate analysis of the immunological modifications following HCV eradication. We studied the dynamics of blood myeloid dendritic cells, monocytes, slan-DCs, and T lymphocytes during IFN-free and IFN-based regimens in hepatitis C virus infection.

Indexed as

AdultAgedAntiviral AgentsDendritic CellsFemaleFibrosisHepacivirusHepatitis C, ChronicHumansImmunity, InnateImmunotherapyInterferon-alphaLiverLymphocyte ActivationMaleMiddle AgedAntiviral AgentsInterferon-alpha

Identifiers

PMID32258171
PMCPMC7102477
OpenAlexW3011271964

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.