Observational studyBioMed research international2020
Association of Serum Uric Acid with Metabolic Syndrome and Its Components: A Mendelian Randomization Analysis.
Observational study in BioMed research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Can biomarkers be used to improve diagnosis and prediction of metabolic syndrome in childhood cancer survivors? A systematic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2021Pooled it
- Association of ABCG2 gene variants with urate levels in Mexican patients with type 2 diabetes and chronic kidney disease.Scientific reports · 2026Article
- Study on the correlation between hyperuricemia and components of metabolic syndrome in T2DM in China: a single-center, observational study.Frontiers in endocrinology · 2026Observational
- Sex-Differential Association Between Serum Uric Acid and Incident Hypertension in a Chinese Population With Normal Body Mass Index: A Prospective Observational Study.Reviews in cardiovascular medicine · 2025Article
- The association between serum uric acid levels and the cardiometabolic phenotype among healthcare workers of Tabriz University of Medical Sciences.Journal of cardiovascular and thoracic research · 2025Article
- Article
- The Association between Uric Acid and Metabolic Syndrome in a Middle-Aged and Elderly Taiwanese Population: A Community-Based Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2024Article
- Correlation Analysis between Uric Acid and Metabolic Syndrome in the Chinese Elderly Population: A Cross-Sectional Study.International journal of endocrinology · 2023Article
- Association between Serum Uric Acid and Hypertension in a Large Cross-Section Study in a Chinese Population.Journal of cardiovascular development and disease · 2022Article
- Excess comorbidities in gout: the causal paradigm and pleiotropic approaches to care.Nature reviews. Rheumatology · 2022Review
- Detection and Correlation Analysis of Serum Uric Acid in Patients with Thyroid-Associated Ophthalmopathy.Computational and mathematical methods in medicine · 2022Article
- Dietary and Lifestyle-Centered Approach in Gout Care and Prevention.Current rheumatology reports · 2021Review
- Visit-to-visit variability of serum uric acid measurements and the risk of all-cause mortality in the general population.Arthritis research & therapy · 2021Article
- Uric Acid and Hypertension: Prognostic Role and Guide for Treatment.Journal of clinical medicine · 2021Review
- The Effects of Cardiometabolic Factors on the Association Between Serum Uric Acid and Chronic Kidney Disease in Chinese Middle-Aged and Older Population: A Mediation Analysis.Frontiers in endocrinology · 2021Article
- Association between Lipid Profiles and Serum Urate: A Cross-Sectional Study in Southwestern China.International journal of endocrinology · 2021Article
- Polymorphisms of the genesF1000Research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of uric acid on metabolic syndrome (MetS) has always been controversial. This study aims to explore associations between uric acid with MetS and its components in Chinese female health check-up population.
methods1381 subjects constituted the longitudinal health check-up cohort. Health examination and genotyping were performed. Unadjusted and adjusted observational analyses were implemented to evaluate observational associations between uric acid with MetS and its components. Mendelian randomization analysis was performed to estimate the causal effect using variation at rs11722228 (
resultsAn increase of 65% in risk of MetS per standard deviation increase in uric acid was found using unadjusted observational analyses. This association attenuated on adjustment for potential confounders. Similar patterns were found in the association analyses of uric acid with hyperglycemia, hypertension, and dyslipidemia. Neither by performing unadjusted nor adjusted analysis did we see evidence for association of uric acid on overweight and obesity. Mendelian randomization analyses showed no evidence of causal association between uric acid and MetS and MetS components.
conclusionsWe found no causal evidence to support that increased serum uric acid is a causal risk factor for MetS or its components. Hence, there remains no strong evidence for the effeteness of undergoing urate-lowering therapy to prevent the onset of MetS or cardiovascular disease in health management.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.