Evidence map›Paper›PMID 32257957›Full record

ArticleEuropean thyroid journal2020

Taller-Than-Wide Shape: A New Definition Improves the Specificity of TIRADS Systems.

Giorgio Grani, Livia Lamartina, Valeria Ramundo, Rosa Falcone, Cristiano Lomonaco, Laura Ciotti, Martina Barone, Marianna Maranghi, Vito Cantisani, Sebastiano Filetti and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in European thyroid journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Taller-than-wide as a red flag for malignancy in ultrasound of parotid gland tumors.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  7. Article
  8. Thyroid Nodule Sphericity Metrics Discriminate Benign and Malignant Follicular and Oncocytic Neoplasms.Thyroid : official journal of the American Thyroid Association · 2025
    Article
  9. Thyroid nodules: diagnosis and management.Nature reviews. Endocrinology · 2024
    Review
  10. Review
  11. Article
  12. Article
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  14. Should we reconsider high-risk features in thyroid ultrasonography?Revista da Associacao Medica Brasileira (1992) · 2023
    Article
  15. Thyroid Nodule Shape Independently Predicts Risk of Malignancy.The Journal of clinical endocrinology and metabolism · 2022
    Article
  16. Review
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  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Giorgio GraniDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Livia LamartinaDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Valeria RamundoDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Rosa FalconeDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Cristiano LomonacoDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Laura CiottiDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Martina BaroneDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Marianna MaranghiDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Vito CantisaniDiagnostic and Ultrasound Innovations Unit, Azienda Ospedaliera Universitaria Policlinico Umberto I, "Sapienza" University of Rome, Rome, Italy.
Sebastiano FilettiDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Cosimo DuranteDepartment of Translational and Precision Medicine, "Sapienza" University of Rome, Rome, Italy.
Sapienza University of Rome · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA taller-than-wide (TTW) shape is a suspicious feature of thyroid nodules commonly defined as an anteroposterior/transverse diameter (AP/T) ratio >1. An intraobserver variability of up to 18% in AP diameter evaluations has been described, which may lead to overreporting of this feature. To potentially improve the reliability of the TTW definition, we propose an arbitrary ratio of ≥1.2.

objectiveThe aim of this study was to estimate the impact of this definition on diagnostic performance.

methodsWe prospectively analyzed 553 thyroid nodules referred for cytology evaluation at an academic center. Before fine-needle aspiration, two examiners jointly defined all sonographic features considered in risk stratification systems developed by the American Thyroid Association (ATA), the American Association of Clinical Endocrinologists (AACE), the American College of Radiology (ACR TIRADS), the European Thyroid Association (EU-TIRADS), and the Korean Society of Thyroid Radiology (K-TIRADS). TTW was defined according to the current definition (AP/T diameter ratio >1) and an arbitrary alternative definition (AP/T ratio >1.2).

resultsThe alternative definition classified fewer nodules as TTW (28, 5.1% vs. 94, 17%). The current and proposed definitions have a sensitivity of 26.2 and 11.9% (

conclusionsRe-defining TTW nodules as those with an AP/T ratio ≥1.2 improves this marker's specificity for malignancy. Using this definition in risk stratification systems will increase their specificity, reducing the number of suggested biopsies without significantly diminishing their overall diagnostic performance.

Indexed as

Reproducibility of resultsSensitivity and specificityThyroid noduleUltrasonographyUltrasound

Identifiers

PMID32257957
PMCPMC7109429
OpenAlexW2986990900

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.