Evidence map›Paper›PMID 32257861›Full record

ReviewTranslational andrology and urology2020

Towards a better testicular sperm extraction: novel sperm sorting technologies for non-motile sperm extracted by microdissection TESE.

Cathy L Mangum, Darshan P Patel, Alexander R Jafek, Raheel Samuel, Tim G Jenkins, Kenneth I Aston, Bruce K Gale, James M Hotaling

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational andrology and urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. The Future of IVF: The New Normal in Human Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2022
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Cathy L MangumDivision of Urology, Department of Surgery, University of Utah Health, Salt Lake City, UT, USA.
Darshan P PatelDivision of Urology, Department of Surgery, University of Utah Health, Salt Lake City, UT, USA.
Alexander R JafekDepartment of Mechanical Engineering, Department of Surgery (Urology), University of Utah, Salt Lake City, UT, USA.
Raheel SamuelDepartment of Mechanical Engineering, Department of Surgery (Urology), University of Utah, Salt Lake City, UT, USA.
Tim G JenkinsDivision of Urology, Department of Surgery, University of Utah Health, Salt Lake City, UT, USA.
Kenneth I AstonDivision of Urology, Department of Surgery, University of Utah Health, Salt Lake City, UT, USA.
Bruce K GaleDepartment of Mechanical Engineering, Department of Surgery (Urology), University of Utah, Salt Lake City, UT, USA.
James M HotalingDivision of Urology, Department of Surgery, University of Utah Health, Salt Lake City, UT, USA.
University of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-obstructive azoospermia (NOA) is the most severe form of male factor infertility. It is characterized by a lack of spermatogenesis in the seminiferous tubules. Microdissection testicular sperm extraction (microTESE) has significantly improved testicular sperm retrieval rates compared to conventional techniques for NOA. Following testicular biopsy, the sperm is usually non-motile and contained within seminiferous tubules requiring extensive laboratory processing to find individual sperm sufficient for artificial reproductive technologies (ART). Current techniques include mechanical and enzymatic processing which is time-consuming and often damaging to sperm. We review novel techniques that may help improve sperm retrieval rates after microTESE including microfluidics (dielectrophoretic cell sorting, spiral channel sorting, and pinched flow fractionation), fluorescence-activated cell sorting (FACS), and magnetic-activated cell sorting (MACS).

Indexed as

azoospermia/therapyintracytoplasmic/methodsmalemicrodissection/methodsMicrofluidicssperm injectionssperm retrievalsperm separation

Identifiers

PMID32257861
PMCPMC7108989
OpenAlexW2972886665

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.