Evidence map›Paper›PMID 32257815›Full record

ArticleMolecular genetics and metabolism reports2020

Alice P Sowton, Nisha Padmanabhan, Simon J Tunster, Ben D McNally, Antonio Murgia, Aisha Yusuf, Julian L Griffin, Andrew J Murray, Erica D Watson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular genetics and metabolism reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Alice P SowtonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Nisha PadmanabhanDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Simon J TunsterDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Ben D McNallyDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Antonio MurgiaDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Aisha YusufDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Julian L GriffinDepartment of Biochemistry, University of Cambridge, Cambridge, CB2 1GA, UK.
Andrew J MurrayDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
Erica D WatsonDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3EG, UK.
University of Cambridge · GBImperial College London · GB

Funding

Medical Research Council MC_PC_13030Medical Research Council MR/P011705/1Medical Research Council MR/P011705/2Medical Research Council MR/P01836X/1
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is associated with dietary folate deficiency and mutations in genes required for one‑carbon metabolism. However, the mechanism through which this occurs is unclear. To improve our understanding of this link, we investigated liver morphology, metabolism and fuel storage in adult mice with a hypomorphic mutation in the gene methionine synthase reductase (

Indexed as

5-methyl-THF, 5-methyltetrahydofolateAgl, amylo-alpha-1,6-glucosidase,4-alpha-glucanotransferase geneBCA, bicinchoninic acidBhmt, betaine-homocysteine S-methyltransferase geneCebpa, CCAAT/enhancer binding protein (C/EBP), alpha geneCE, cholesteryl-esterCer, ceramideDAG, diacylglycerolDdit3, DNA damage inducible transcript 3 geneETS, electron transport systemFCCP, p-trifluoromethoxyphenyl hydrazineFFA, free fatty acidG6pc, glucose 6-phophastase geneGbe1, glycogen branching enzyme 1 geneGlycogenGsk3, glycogen synthase kinase genegt, gene-trapGyg, glycogenin geneGys2, glycogen synthase 2 geneHepatic fuel storageHOAD, 3-hydoxyacyl-CoA dehydrogenaseIsca1, iron‑sulfur cluster assembly 1 geneJO2, oxygen fluxLC-MS, liquid chromatography-mass spectrometryLipidomicsLiver metabolismLPC, lysophosphatidylcholineMitochondrial functionMthfr, methylenetetrahydrofolate reductase geneMtr, methionine synthase gene (also MS)Mtrr, methionine synthase reductase gene (also MSR)Myc, myelocytomatosis oncogeneNAFLD, non-alcoholic fatty liver diseaseNASH, non-alcoholic steatohepatitisNdufs, NADH:ubiquinone oxidoreductase core subunit (ETS complex I) geneOne‑carbon metabolismOXPHOS, oxidative phosphorylationPA, phosphatidic acidPAS, periodic acid SchiffPC, phosphatidylcholinePE, phosphatidylethanolaminePG, phosphatidylglycerolPI, phosphatidylinositolPIP, phosphatidylinositol phosphate(s)PL, phospholipidPS, phosphatidylserineRIPA, Radioimmunoprecipitation assaySAH, S-adenosylhomocysteineSAM, S-adenosylmethionineSM, sphingomyelinTAG, triacylglycerolUgp2, UDP-glucose pyrophophorylase 2 gene

Identifiers

PMID32257815
PMCPMC7109458
OpenAlexW3013097376

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.