ReviewCureus2020
Role of Prophylactic Antibiotics in Critical Care of Stroke Patients - A Preventive Approach to Post-stroke Infections?
Review in Cureus, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.
- Procalcitonin and biomarkers for stroke-associated pneumonia: a systematic review and meta-analysis.BMC pulmonary medicine · 2025Pooled it
- The Neutrophil to Lymphocyte Ratio in Poststroke Infection: A Systematic Review and Meta-Analysis.Disease markers · 2022Pooled it
- Influence of prophylactic antibiotics on incidence of urinary tract infections in acute-to-subacute patients with stroke and asymptomatic bacteriuria.Scientific reports · 2025Article
- Gastrointestinal Dysfunction and Dysbiosis in Ischemic Stroke: Opportunities for Therapeutic Intervention.Pharmaceuticals (Basel, Switzerland) · 2025Review
- The impact of airway management guided by Protection Motivation Theory on the prevention and prognosis of post-stroke pneumonia.Frontiers in neurology · 2025Article
- Comparison of admitting neutrophil/lymphocyte ratio with baseline NIH stroke scale score in discriminating poor 30-day stroke outcome among Nigerian Africans.Frontiers in stroke · 2025Article
- A Single-Center Retrospective Study of Bacterial Infections After Acute Ischemic Stroke: The Prevalence Before and During the COVID-19 Pandemic.Medicina (Kaunas, Lithuania) · 2024Article
- Periodontal Disease in Patients with Ischemic Stroke - an Exploratory Study.Acta stomatologica Croatica · 2024Article
- A prospective observational study of estimating drug related problems and clinical outcomes in subtypes of stroke patients.PloS one · 2024Observational
- Post stroke aspiration pneumonia, associated factors, and treatment outcome among stroke patients admitted to Tibebe Ghion Specialized Hospital, Bahir Dar, Ethiopia.Frontiers in stroke · 2024Article
- The effects of regular dental scaling on the complications and mortality after stroke: a retrospective cohort study based on a real-world database.BMC oral health · 2023Article
- Interventional strategies for ischemic stroke based on the modulation of the gut microbiota.Frontiers in neuroscience · 2023Review
- Review
- Triggering of cardiovascular disease by infection type: The Atherosclerosis Risk in Communities study (ARIC).International journal of cardiology · 2021Article
- Gut dysbiosis and age-related neurological diseases; an innovative approach for therapeutic interventions.Translational research : the journal of laboratory and clinical medicine · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Post-stroke complications are very common worldwide and the most common complication is infection. This contributes the most to the mortality rate in stroke patients. Among the infections, pneumonia and urinary tract infections are most common. Hyperthermia following stroke is associated with neuronal damage and worse outcomes. Post-stroke immunosuppression and activation of inflammatory mediators also cause infections. Based on the high mortality caused by post-stroke infections, various trials were done to seek the advantage that prophylactic antibiotics can give in the critical care of stroke patients. Antibiotics, including ceftriaxone (cephalosporin), levofloxacin (fluoroquinolone), penicillin, and minocycline (tetracycline), were used and the stroke patients were followed up to analyze the primary and secondary outcomes. It was concluded that early antibiotic therapy (mostly within 24 hours) leads to a reduced rate of post-stroke infections and reduced fever spikes, whereas follow-up for a longer period of time showed no better functional outcome. Furthermore, mortality and morbidity benefits were also not seen with prophylactic antibiotic therapy. This review helped us to put a nail in the coffin to the earlier thoughts that prophylactic antibiotics are necessary for the critical care of stroke patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.