Evidence map›Paper›PMID 32257583›Full record

ArticleACS catalysis2019

Crystal Structure of the Ergothioneine Sulfoxide Synthase from

Nathchar Naowarojna, Seema Irani, Weiyao Hu, Ronghai Cheng, Li Zhang, Xinhao Li, Jiesheng Chen, Yan Jessie Zhang, Pinghua Liu

Abstract read
In one paragraph

Article in ACS catalysis, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Insights into the pH-dependent reactivity and substrate induced active-site reorganization of the non- heme iron enzyme CthEgtB.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2026
    Article
  2. Review
  3. Review
  4. Article
  5. Synthesis of Diaryl- and Dialkynylphosphinates From Ubiquitous PAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  6. Enhanced production of ergothioneine in Aspergillus oryzae.Applied microbiology and biotechnology · 2025
    Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. A SingleInternational journal of molecular sciences · 2022
    Article
  14. Article
  15. Review
  16. OvoAChemical science · 2022
    Article
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Nathchar NaowarojnaDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Seema IraniDepartment of Molecular Biosciences and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, United States.
Weiyao HuDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Ronghai ChengDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Li ZhangDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.
Xinhao LiSchool of Chemistry and Chemical Engineering, Shanghai JiaoTong University, Shanghai 200240, China.
Jiesheng ChenSchool of Chemistry and Chemical Engineering, Shanghai JiaoTong University, Shanghai 200240, China.ORCID 0000-0003-1233-7746
Yan Jessie ZhangDepartment of Molecular Biosciences and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas 78712, United States.
Pinghua LiuDepartment of Chemistry, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States.ORCID 0000-0002-9768-559X

Funding

Gene-specific transcriptional silencing directed by dephosphorylation of RNAP IIR01GM104896 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI ZHANG, YAN JESSIE · 2013 to 2022
$2.4M
Interpretation of the phosphorylation code of RNA polymerase II during eukaryotic transcriptionR01GM125882 · NIGMS · UNIVERSITY OF TEXAS AT AUSTIN · PI BRODBELT, JENNIFER S., ZHANG, YAN JESSIE · 2018 to 2021
$1.4M
NIGMS NIH HHS R01 GM104896NIGMS NIH HHS R01 GM125882
6 · The paper itself

Abstract

Ergothioneine is a thiohistidine derivative with potential benefits on many aging-related diseases. The central step of aerobic ergothioneine biosynthesis is the oxidative C-S bond formation reaction catalyzed by mononuclear nonheme iron sulfoxide synthases (EgtB and Egt1). Thus far, only the

Indexed as

enzyme engineeringergothioneinenonheme iron enzymeRosetta Enzyme Designsulfur-containing natural product

Identifiers

PMID32257583
PMCPMC7133768

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.