ArticleJournal of analytical methods in chemistry2020
An Analytical Perspective on Determination of Free Base Nicotine in E-Liquids.
Article in Journal of analytical methods in chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- The Effects of Individual Components of E-Cigarettes on Ion Transport and Airway Surface Liquid Height in Human Bronchial Epithelial Cells.Medicina (Kaunas, Lithuania) · 2025Article
- Determination of Nicotine Protonation State in E-Liquids by Low-Resolution Benchtop NMR Spectroscopy.Chemical research in toxicology · 2024Article
- Comparison of genotoxic impurities in extracted nicotine vs. synthetic nicotine.Frontiers in chemistry · 2024Article
- Direct Extraction and Determination of Free Nicotine in Cigarette Smoke.Journal of analytical methods in chemistry · 2024Article
- Effects of Device Settings and E-Liquid Characteristics on Mouth-Throat Losses of Nicotine Delivered with Electronic Nicotine Delivery Systems (ENDS).Journal of aerosol science · 2023Article
- Chemical characterisation of the vapour emitted by an e-cigarette using a ceramic wick-based technology.Scientific reports · 2022Article
- Direct Determination of Free Nicotine Content in Tobacco.ACS omega · 2022Article
- E-Liquids from Seven European Countries-Warnings Analysis and Freebase Nicotine Content.Toxics · 2022Article
- Potential factors affecting free base nicotine yield in electronic cigarette aerosols.Expert opinion on drug delivery · 2021Article
- Nicotine forms: why and how do they matter in nicotine delivery from electronic cigarettes?Expert opinion on drug delivery · 2020Review
- Free-Base Nicotine Fraction αChemical research in toxicology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
In electronic cigarette users, nicotine delivery to lungs depends on various factors. One of the important factors is e-liquid nicotine concentration. Nicotine concentration in e-liquids ranges from 0 to >50 mg/mL. Furthermore, nicotine exists in protonated and unprotonated ("free base") forms. The two forms are believed to affect the nicotine absorption in body. Therefore, in addition to total nicotine concentration, e-liquids should be characterized for their free base nicotine yield. Two approaches are being used for the determination of free base nicotine in e-liquids. The first is applying a dilution to e-liquids followed by two methods: Henderson-Hasselbalch theory application or a Liquid-Liquid Extraction. The second is the without-dilution approach followed by
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.