ArticleRoyal Society open science2020
Fluid-structure interaction simulations outperform computational fluid dynamics in the description of thoracic aorta haemodynamics and in the differentiation of progressive dilation in Marfan syndrome patients.
Article in Royal Society open science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Alterations in ascending aortic hemodynamics and aortic length correlate with sex-specific thoracic aortic aneurysm dilation and lifespan in a mouse model of severe Marfan syndrome.Computers in biology and medicine · 2026Article
- A combined 4D flow MR imaging and fluid-structure interaction analysis of ascending thoracic aortic aneurysms.Biomechanics and modeling in mechanobiology · 2025Article
- The interdependent hemodynamic influence between abdominal aortic aneurysm and renal artery stenosis.Scientific reports · 2024Article
- Investigations of Differential Hypoxemia During Venoarterial Membrane Oxygenation with and Without Impella Support.Cardiovascular engineering and technology · 2024Article
- A comprehensive MRI-based computational model of blood flow in compliant aorta using radial basis function interpolation.Biomedical engineering online · 2024Article
- Numerical flow experiment for assessing predictors for cerebrovascular accidents in patients with PHACES syndrome.Scientific reports · 2024Article
- In Vivo Efficacy of an Adhesive Bioresorbable Patch to Treat Aortic Dissections.JACC. Basic to translational science · 2024Article
- Simulating Subject-Specific Aortic Hemodynamic Effects of Valvular Lesions in Rheumatic Heart Disease.Journal of biomechanical engineering · 2023Article
- Fast Approximate Quantification of Endovascular Stent Graft Displacement Forces in the Bovine Aortic Arch Variant.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2023Article
- Modeling Dynamics of the Cardiovascular System Using Fluid-Structure Interaction Methods.Biology · 2023Review
- Validation of the Reduced Unified Continuum Formulation Against In Vitro 4D-Flow MRI.Annals of biomedical engineering · 2023Article
- A Pilot Study Characterizing Flow Patterns in the Thoracic Aorta of Patients With Connective Tissue Disease: Comparison to Age- and Gender-Matched ControlsFrontiers in pediatrics · 2022Article
- A novel MRI-based data fusion methodology for efficient, personalised, compliant simulations of aortic haemodynamics.Journal of biomechanics · 2021Article
- On the Role and Effects of Uncertainties in CardiovascularFrontiers in medical technology · 2021Article
- Fully-Coupled FSI Computational Analyses in the Ascending Thoracic Aorta Using Patient-Specific Conditions and Anisotropic Material Properties.Frontiers in physiology · 2021Article
- Fluid-structure interaction simulations outperform computational fluid dynamics in the description of thoracic aorta haemodynamics and in the differentiation of progressive dilation in Marfan syndrome patients.Royal Society open science · 2020Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Abnormal fluid dynamics at the ascending aorta may be at the origin of aortic aneurysms. This study was aimed at comparing the performance of computational fluid dynamics (CFD) and fluid-structure interaction (FSI) simulations against four-dimensional (4D) flow magnetic resonance imaging (MRI) data; and to assess the capacity of advanced fluid dynamics markers to stratify aneurysm progression risk. Eight Marfan syndrome (MFS) patients, four with stable and four with dilating aneurysms of the proximal aorta, and four healthy controls were studied. FSI and CFD simulations were performed with MRI-derived geometry, inlet velocity field and Young's modulus. Flow displacement, jet angle and maximum velocity evaluated from FSI and CFD simulations were compared to 4D flow MRI data. A dimensionless parameter, the shear stress ratio (SSR), was evaluated from FSI and CFD simulations and assessed as potential correlate of aneurysm progression. FSI simulations successfully matched MRI data regarding descending to ascending aorta flow rates (
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