Evidence map›Paper›PMID 32257209›Full record

ArticleClinical & translational immunology2020

UV radiation recruits CD4

Nathan J Hawkshaw, Suzanne M Pilkington, Sharon A Murphy, Norah Al-Gazaq, Mark D Farrar, Rachel Eb Watson, Anna Nicolaou, Lesley E Rhodes

Open access · goldAbstract read
In one paragraph

Article in Clinical & translational immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Article
  3. The effects of exposure to solar radiation on human health.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023
    Article
  4. Article
  5. Article
  6. Review
  7. Environmental effects of stratospheric ozone depletion, UV radiation, and interactions with climate change: UNEP Environmental Effects Assessment Panel, Update 2020.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Nathan J HawkshawCentre for Dermatology Research Division of Musculoskeletal and Dermatological Sciences Faculty of Biology, Medicine and Health School of Biological Sciences Manchester Academic Health Science Centre The University of Manchester and Salford Royal NHS Foundation Trust Manchester UK.
Suzanne M PilkingtonCentre for Dermatology Research Division of Musculoskeletal and Dermatological Sciences Faculty of Biology, Medicine and Health School of Biological Sciences Manchester Academic Health Science Centre The University of Manchester and Salford Royal NHS Foundation Trust Manchester UK.
Sharon A MurphyLaboratory for Lipidomics and Lipid Biology Division of Pharmacy and Optometry Faculty of Biology Medicine and Health School of Health Sciences The University of Manchester Manchester UK.
Norah Al-GazaqLaboratory for Lipidomics and Lipid Biology Division of Pharmacy and Optometry Faculty of Biology Medicine and Health School of Health Sciences The University of Manchester Manchester UK.
Mark D FarrarCentre for Dermatology Research Division of Musculoskeletal and Dermatological Sciences Faculty of Biology, Medicine and Health School of Biological Sciences Manchester Academic Health Science Centre The University of Manchester and Salford Royal NHS Foundation Trust Manchester UK.
Rachel Eb WatsonCentre for Dermatology Research Division of Musculoskeletal and Dermatological Sciences Faculty of Biology, Medicine and Health School of Biological Sciences Manchester Academic Health Science Centre The University of Manchester and Salford Royal NHS Foundation Trust Manchester UK.
Anna NicolaouLaboratory for Lipidomics and Lipid Biology Division of Pharmacy and Optometry Faculty of Biology Medicine and Health School of Health Sciences The University of Manchester Manchester UK.
Lesley E RhodesCentre for Dermatology Research Division of Musculoskeletal and Dermatological Sciences Faculty of Biology, Medicine and Health School of Biological Sciences Manchester Academic Health Science Centre The University of Manchester and Salford Royal NHS Foundation Trust Manchester UK.
University of Manchester · GBSalford Royal NHS Foundation Trust · GBManchester Academic Health Science Centre · GB

Funding

Wellcome Trust
6 · The paper itself

Abstract

objectivesSolar ultraviolet radiation (UVR) has major adverse effects on human health. While the mechanisms responsible for induction of UVR-induced inflammation are well-documented, the mediation of its resolution and longer-term adaptive homeostasis is unknown. Therefore, we examined the skin immune and lipid profile over time following UVR inflammation.

methodsTo investigate the self-resolving events of UVR inflammation

resultsWe identified that cellular resolution events including switching of macrophage phenotype apply to human sunburn. However, UVR-induced inflammation in humans involves a post-resolution phase that differs from other experimental models. We demonstrate that 2 weeks after the initiating UVR stimulus, there is considerable immune activity with CD8

conclusionWe have identified for the first time that CD4

Indexed as

immunosuppressioninflammationlipidomicsresolutionT cellsultraviolet radiation

Identifiers

PMID32257209
PMCPMC7114692
OpenAlexW3000476770

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.