Evidence map›Paper›PMID 32257060›Full record

ArticleAuto- immunity highlights2019

Neutrophil/lymphocyte ratio and lymphocyte/monocyte ratio in ulcerative colitis as non-invasive biomarkers of disease activity and severity.

Ashraf M Okba, Mariam M Amin, Ahmed S Abdelmoaty, Hend E Ebada, Amgad H Kamel, Ahmed S Allam, Omar M Sobhy

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Auto- immunity highlights, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04818788 (Hematological Indices and Fecal Calprotectin as Predictors of Histological Remission in Ulcerative Colitis Patients Receiving Biological Therapy), which is not on this map. Cited by 32 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04818788 unknown statusnot on this mapstarted 2021, after this paper: background citation

Hematological Indices and Fecal Calprotectin as Predictors of Histological Remission in Ulcerative Colitis Patients Receiving Biological Therapy

TypeobservationalSponsorAssiut UniversityRan2021 to 2022Enrolled24ConditionsUlcerative ColitisArmsBiological Drug
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Can Neutrophil/Lymphocyte Ratio Assess Inflammatory Bowel Disease Activity and Severity in Children?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashraf M Okba1Department of Internal Medicine, Clinical Immunology and Allergy, Ain Shams University, Cairo, Egypt.
Mariam M Amin1Department of Internal Medicine, Clinical Immunology and Allergy, Ain Shams University, Cairo, Egypt.ORCID 0000-0003-2579-0275
Ahmed S Abdelmoaty2Department of Tropical Medicine, Ain Shams University, Cairo, Egypt.
Hend E Ebada2Department of Tropical Medicine, Ain Shams University, Cairo, Egypt.
Amgad H Kamel2Department of Tropical Medicine, Ain Shams University, Cairo, Egypt.
Ahmed S Allam3Department of Internal Medicine, Ain Shams University, Cairo, Egypt.
Omar M Sobhy1Department of Internal Medicine, Clinical Immunology and Allergy, Ain Shams University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundApart from endoscopic interventions, readily attainable cost-effective biomarkers for ulcerative colitis (UC) assessment are required. For this purpose, we evaluated differential leucocytic ratio, mainly neutrophil-lymphocyte ratio (NLR) and lymphocyte-monocyte ratio (LMR) as simple available indicators of disease activity in patients with ulcerative colitis.

methodsStudy conducted on 80 UC patients who were classified into two groups of 40 each according to Mayo score and colonoscopic findings. Group 1 (active UC) and group 2 (inactive UC). Another 40 group-matched healthy participants were enrolled. White blood cell count, NLR, LMR, C-reactive protein, and Erythrocyte sedimentation rate were measured and recorded.

resultsSignificant elevation of NLR was observed in active UC group compared to inactive UC and controls (2.63 ± 0.43, 1.64 ± 0.25, 1.44 ± 0.19 respectively; p < 0.0001). The optimal NLR cut-off value for active UC was > 1.91, with a sensitivity and a specificity of 90% and 90% respectively. The mean LMRs of active UC was significantly lower compared with inactive UC patients and controls (2.25 ± 0.51, 3.58 ± 0.76, 3.64 ± 0.49 respectively; p < 0.0001). The cut-off value of LMR for determining the disease activity was ≤ 2.88 with a sensitivity of 90% and a specificity of 90%. NLR, LMR, and CRP were found to be significant independent markers for discriminating disease activity (p = 0.000). Besides, NLR was significantly higher in patients with pancolitis and positively correlated with endoscopically severe disease.

conclusionNLRs and LMRs are simple non-invasive affordable independent markers of disease activity in UC.

Indexed as

Disease activityMonocyte–lymphocyte ratioNeutrophil–lymphocyte ratioUlcerative colitis

Identifiers

PMID32257060
PMCPMC6909025

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.