Evidence map›Paper›PMID 32256964›Full record

ArticleOxidative medicine and cellular longevity2020

DpdtC-Induced EMT Inhibition in MGC-803 Cells Was Partly through Ferritinophagy-Mediated ROS/p53 Pathway.

Jiankang Feng, Cuiping Li, Ruifang Xu, Yongli Li, Qi Hou, Rui Feng, Senye Wang, Lei Zhang, Changzheng Li

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 25 citations in OpenAlex.

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  7. Ferritinophagy induced ferroptosis in the management of cancer.Cellular oncology (Dordrecht, Netherlands) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jiankang FengDepartement of Molecular Biology and Biochemistry, Xinxiang Medical University, Xinxiang, Henan, China 453003.
Cuiping LiDepartement of Molecular Biology and Biochemistry, Xinxiang Medical University, Xinxiang, Henan, China 453003.
Ruifang XuExperimental Teaching Center of Biology and Basic Medical Sciences, Sanquan College of Xinxiang Medical University, Xinxiang, Henan, China 453003.
Yongli LiDepartment of Histology and Embryology, Sanquan College of Xinxiang Medical University, Xinxiang, Henan, China 453003.ORCID https://orcid.org/0000-0001-7293-5313
Qi HouDepartment of Histology and Embryology, Sanquan College of Xinxiang Medical University, Xinxiang, Henan, China 453003.
Rui FengExperimental Teaching Center of Biology and Basic Medical Sciences, Sanquan College of Xinxiang Medical University, Xinxiang, Henan, China 453003.
Senye WangExperimental Teaching Center of Biology and Basic Medical Sciences, Sanquan College of Xinxiang Medical University, Xinxiang, Henan, China 453003.
Lei ZhangExperimental Teaching Center of Biology and Basic Medical Sciences, Sanquan College of Xinxiang Medical University, Xinxiang, Henan, China 453003.
Changzheng LiDepartement of Molecular Biology and Biochemistry, Xinxiang Medical University, Xinxiang, Henan, China 453003.ORCID https://orcid.org/0000-0002-6226-5843
Xinxiang Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epithelial-mesenchymal transition (EMT) is a cellular process in which epithelial cells are partially transformed into stromal cells, which endows the polarized epithelium cells more invasive feature and contributes cancer metastasis and drug resistance. Ferritinophagy is an event of ferritin degradation in lysosomes, which contributes Fenton-mediated ROS production. In addition, some studies have shown that ROS participates in EMT process, but the effect of ROS stemmed from ferritin degradation on EMT has not been fully established. A novel iron chelator, DpdtC (2,2'-di-pyridylketone dithiocarbamate), which could induce ferritinophagy in HepG2 cell in our previous study, was used to investigate its effect on EMT in gastric cancer cells. The proliferation assay showed that DpdtC treatment resulted in growth inhibition and morphologic alteration in MGC-803 cell (IC

Indexed as

AutophagyDitiocarbEpithelial-Mesenchymal TransitionFerritinsHumansReactive Oxygen SpeciesTumor Suppressor Protein p53di-n-propyldithiocarbamateDitiocarbFerritinsReactive Oxygen SpeciesTumor Suppressor Protein p53

Identifiers

PMID32256964
PMCPMC7091554
OpenAlexW3011040676

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.