Evidence map›Paper›PMID 32256939›Full record

ArticleThe World Allergy Organization journal2020

International expert consensus on the management of allergic rhinitis (AR) aggravated by air pollutants: Impact of air pollution on patients with AR: Current knowledge and future strategies.

Robert Naclerio, Ignacio J Ansotegui, Jean Bousquet, G Walter Canonica, Gennaro D'Amato, Nelson Rosario, Ruby Pawankar, David Peden, Karl-Christian Bergmann, Leonard Bielory and 13 more

Open access · goldAbstract read
In one paragraph

Article in The World Allergy Organization journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 175 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. [Sleep disorders associated with montelukast in children with respiratory allergy].Revista medica del Instituto Mexicano del Seguro Social · 2026
    Article
  4. The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases.World journal of otorhinolaryngology - head and neck surgery · 2026
    Review
  5. Unmasking the Impact of Air Pollution on Allergic Rhinitis.Clinical reviews in allergy & immunology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Observational
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Twenty-five years: The fexofenadine clinical experience.The World Allergy Organization journal · 2024
    Review
  18. [Analysis of allergen distribution and indoor factors in allergic rhinitis in Chaoshan area].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2024
    Article
  19. The Impact of Fine Particulate Matter on Embryonic Development.International journal of molecular sciences · 2024
    Article
  20. Impact of climate change on paediatric respiratory health: pollutants and aeroallergens.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review

9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 20 institutions in 12 countries.

Robert NaclerioJohns Hopkins School of Medicine, Baltimore, MD, USA.
Ignacio J AnsoteguiDepartment of Allergy & Immunology, Hospital Quironsalud Bizkaia- Bilbao, Spain.
Jean BousquetINSERM U 1168, VIMA: Ageing and Chronic Diseases Epidemiological and Public Health Approaches, Villejuif, France.
G Walter CanonicaHumanitas University & Research Hospital, Milano, Italy.
Gennaro D'AmatoDivision of Respiratory and Allergic Diseases, High Specialty Hospital A. Cardarelli, Napoli, Italy; School of Specialization in Respiratory Diseases University Federico II Naples, Italy.
Nelson RosarioPediatric Respiratory Medicine Division, Complexo Hospital de Clinicas, UFPR, Curitiba, Brazil.
Ruby PawankarDept. of Pediatrics, Nippon Medical School, Tokyo, Japan.
David PedenUNC Center for Environmental Medicine, Asthma, and Lung Biology; Division of Allergy, Immunology and Rheumatology, Dpt. of Pediatrics UNS School of Medicine, USA.
Karl-Christian BergmannAllergy-Centre-Charité, Charité-Universita¨tsmedizin Berlin, Berlin, Germany.
Leonard BieloryMedicine & Ophthalmology Hackensack Meridian School of Medicine at Seton Hall University Nutley, New Jersey, USA.
Luis CaraballoInstitute for Immunological Research, University of Cartagena, Cartagena de Indias, Colombia.
Lorenzo CecchiCentre de Bioclimatology, University de Florence, Florence, Italy.
S Alfonso M CepedaFundación Hospital Universitario Metropolitano de Barranquilla, Barranquilla, Colombia.
Herberto José Chong NetoFederal University of Paraná, Brazil.
Carmen GalánDepartment of Botany, Ecology and Plant Physiology, University of Córdoba, Spain.
Sandra N Gonzalez DiazSan Francisco Centro de Especialistas Médicos Monterrey NL, Mexico.
Samar IdrissDepartment of Otolaryngology- Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
Todor PopovAlexander's University Hospital Clinic of Allergy & Asthma, Bulgaria.
German D RamonAlergia e Inmunología, Hospital Italiano Regional del Sur, Bahía Blanca-Buenos Aires, Argentina.
Erminia RidoloDepartment of Clinical and Experimental Medicine, Università; di Parma, Parma, Italy.
Menachem RottemAllergy Asthma and Immunology, Emek Medical Center, Afula, Israel.
Wisuwat SongnuanDepartment of Plant Science, Faculty of Science, Mahidol University, Bangkok, Thailand.
Philip RouadiDepartment of Otolaryngology- Head and Neck Surgery, Eye and Ear University Hospital, Beirut, Lebanon.
Rafik Hariri University Hospital · LBAzienda Usl Toscana Centro · ITCenter for Asthma, Allergy and Respiratory Disease · USCenter for Environmental Health · USCharité - Universitätsmedizin Berlin · DEFederico II University Hospital · ITHospital de Clínicas Universidade Federal do Paraná · BRHospital Quirónsalud Barcelona · ESHumanitas University · ITJohns Hopkins University · USMahidol University · THNippon Medical School · JPSeton Hall University · USTechnion – Israel Institute of Technology · ILTecnológico de Monterrey · MXUniversidade Federal do Paraná · BRUniversidad Metropolitana · COUniversity of Cartagena · COUniversity of Córdoba · ESUniversity of Parma · IT

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
NIEHS NIH HHS P30 ES010126
6 · The paper itself

Abstract

Allergic rhinitis affects the quality of life of millions of people worldwide. Air pollution not only causes morbidity, but nearly 3 million people per year die from unhealthy indoor air exposure. Furthermore, allergic rhinitis and air pollution interact. This report summarizes the discussion of an International Expert Consensus on the management of allergic rhinitis aggravated by air pollution. The report begins with a review of indoor and outdoor air pollutants followed by epidemiologic evidence showing the impact of air pollution and climate change on the upper airway and allergic rhinitis. Mechanisms, particularly oxidative stress, potentially explaining the interactions between air pollution and allergic rhinitis are discussed. Treatment for the management of allergic rhinitis aggravated by air pollution primarily involves treating allergic rhinitis by guidelines and reducing exposure to pollutants. Fexofenadine a non-sedating oral antihistamine improves AR symptoms aggravated by air pollution. However, more efficacy studies on other pharmacological therapy of coexisting AR and air pollution are currently lacking.

Indexed as

AER, Allergic eosinophilic rhinitisAir pollutantsAir pollutionAllergic rhinitisAntioxidant enzymesAP, Activator proteinAR, Allergic rhinitisARE, Antioxidant response elementCFS, Chronic fatigue syndromeClimate changeCO, Carbon monoxideCOPD, Chronic obstructive pulmonary diseaseDAMP, Damage-associated molecular patternsDEP, Diesel exhaust particlesECAT, Elemental carbon attributable to trafficECP, Eosinophil cationic proteinGSH-Px, Glutathione peroxidaseHDM, House dust mitesHEPA, High efficiency particulate airHO, HemeoxygenaseHVAC, Heating, ventilation and air conditioningIAP, Indoor air pollutionIAQ, Indoor air qualityIndoor air qualityINS, Intranasal steroidsLDH, Lactate dehydrogenaseMCP, Monocyte chemotactic proteinMSQPCR, Mold specific quantitative PCRNAR, Non allergic rhinitisNF-κβ, Nuclear factor kappa βNO2, Nitrogen dioxideNOx, Nitric oxidesNrf2, Nuclear factor erythroid-2 related factorO3, OzoneOAP, Outdoor air pollutionOccupational rhinitisOxidative stressPAMP, Pathogen-associated molecular patternsPM, Particulate matterPON, ParaoxonaseRNS, Reactive nitrosative speciesROS, Reactive oxygen speciesSO2, Sulphur dioxideSOD, Superoxide dismutaseTLR, Toll like receptorTNF, Tumor necrosis factorTOS, Total oxidative statusTRAP, Traffic related air pollutantsUFP, Ultra-fine particlesVOCs, Volatile organic compound

Identifiers

PMID32256939
PMCPMC7132263
OpenAlexW3014624655

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.