Evidence map›Paper›PMID 32256866›Full record

ArticleJournal of cardiology cases2020

Disappearance of an anticoagulation-resistant left atrial appendage thrombus after administration of low-dose pimobendan.

Takayuki Sekihara, Takuryu Sonoura, Yuka Nakamura, Isamu Sunayama, Yu Morishita, Masashi Ishimi, Masashi Yamato, Takahiro Yoshimura, Yoshinori Yasuoka

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cardiology cases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Takayuki SekiharaNational Hospital Organization, Osaka-Minami Medical Center, Cardiovascular Division, Osaka Prefecture, Japan.
Takuryu SonouraNational Hospital Organization, Osaka-Minami Medical Center, Cardiovascular Division, Osaka Prefecture, Japan.
Yuka NakamuraNational Hospital Organization, Osaka-Minami Medical Center, Cardiovascular Division, Osaka Prefecture, Japan.
Isamu SunayamaNational Hospital Organization, Osaka-Minami Medical Center, Cardiovascular Division, Osaka Prefecture, Japan.
Yu MorishitaNational Hospital Organization, Osaka-Minami Medical Center, Cardiovascular Division, Osaka Prefecture, Japan.
Masashi IshimiNational Hospital Organization, Osaka-Minami Medical Center, Cardiovascular Division, Osaka Prefecture, Japan.
Masashi YamatoNational Hospital Organization, Osaka-Minami Medical Center, Cardiovascular Division, Osaka Prefecture, Japan.
Takahiro YoshimuraNational Hospital Organization, Osaka-Minami Medical Center, Cardiovascular Division, Osaka Prefecture, Japan.
Yoshinori YasuokaNational Hospital Organization, Osaka-Minami Medical Center, Cardiovascular Division, Osaka Prefecture, Japan.
Osaka Minami Medical Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Anticoagulation therapy is essential for preventing thrombus formation in the left atrial appendage (LAA) and subsequent ischemic strokes in patients with atrial fibrillation (AF). The complete disappearance of any existing LAA thrombi is crucial before AF ablation. Currently, warfarin and direct oral anticoagulants are widely used for this purpose. However, treatment strategies for anticoagulation-resistant LAA thrombi are not well established. Here, we present a case of an 85-year-old male who was scheduled to undergo AF ablation. He developed an LAA thrombus that was resistant to 300 mg/day of dabigatran. Low-dose pimobendan was prescribed in addition to dabigatran; three months later, the thrombus was dissolved successfully. This case demonstrates the potential efficacy of a low-dose oral inotrope for treating an anticoagulation-resistant LAA thrombus. <

Indexed as

Direct oral anticoagulantLeft atrial thrombusPimobendanTransesophageal echocardiography

Identifiers

PMID32256866
PMCPMC7125383
OpenAlexW3000673240

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.