Evidence map›Paper›PMID 32256696›Full record

ArticleEcancermedicalscience2020

Histopathologic patterns of cutaneous malignancies in individuals with oculocutaneous albinism in Anambra state, Nigeria: a paradigm swing?

Nkechi Anne Enechukwu, Gabriel Olabiyi Ogun, Ogochukwu Ifeanyi Ezejiofor, Titus Osita Chukwuanukwu, Joseph Yaria, Adekunle Olufemi George, Adebola Olufunmilayo Ogunbiyi

Open access · goldAbstract read
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In one paragraph

Article in Ecancermedicalscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nkechi Anne EnechukwuDepartment of Internal Medicine, Nnamdi Azikiwe University, Awka, Nnewi Campus, Anambra State, Nigeria.
Gabriel Olabiyi OgunDepartment of Pathology, University College Hospital, Ibadan, Oyo State, Nigeria.
Ogochukwu Ifeanyi EzejioforDepartment of Internal Medicine, Nnamdi Azikiwe University, Awka, Nnewi Campus, Anambra State, Nigeria.
Titus Osita ChukwuanukwuDepartment of Surgery, Nnamdi Azikiwe University, Awka, Nnewi Campus, Anambra State, Nigeria.
Joseph YariaDepartment of Medicine, University College Hospital, Ibadan, Oyo State, Nigeria.
Adekunle Olufemi GeorgeDepartment of Medicine, University College Hospital, Ibadan, Oyo State, Nigeria.
Adebola Olufunmilayo OgunbiyiDepartment of Medicine, University College Hospital, Ibadan, Oyo State, Nigeria.
University College Hospital, Ibadan · NGNnamdi Azikiwe University · NG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundA high proportion of skin cancers in Nigeria occur in Individuals with oculocutaneous albinism (OCA). A reduction or absence of melanin, a skin pigment with photoprotective properties, makes them susceptible to skin malignancies such as squamous cell carcinomas (SCCs), basal cell carcinomas (BCCs) and rarely melanomas. Globally, BCCs are the commonest cutaneous malignancies among Caucasians and in fair-skinned Africans. This has been attributed to the greater effect of melanin in protecting against UV damage in the basal layer of the epidermis. Older retrospective studies on African albinos suggested that SCCs accounted for a higher prevalence of skin cancers in albinos, followed by BCCs. Melanoma has been consistently documented to be rare in all of these reports. Recent reports however noted BCCs to occur at an increasing frequency, suggesting a higher frequency than previously documented. These conflicting reports reflect the need to re-explore the pattern of cutaneous malignancies in albinos in order to reconcile the role of pigmentation, UV exposure and the variance between the frequencies of the different keratinocyte skin cancers among extreme skin phenotypes. This study explores the pattern of cutaneous malignancies seen in albinos in South East Nigeria.

objectiveTo determine the pattern of cutaneous malignancies among albinos in Anambra state, Nigeria. MATERIALS AND

methodsA cross-sectional study conducted in Anambra State, Nigeria. Ninety albinos from the Albino foundation Anambra state were recruited. Malignant dermatoses were characterized clinically and confirmed by histology. Fifty-eight lesions from 30 albinos were biopsied to determine the presence of malignancy.

resultsSkin cancers were seen in 20.98% of all participants and in 18 (60%) of all the albinos who had skin biopsy. The SCC/BCC ratio was 1.0: 2.3. There was no cutaneous melanoma.

conclusionContrary to previous reports, it would appear that the pattern of cutaneous malignancies in albinos shows the same trend as that seen in Caucasians and fair-skinned Africans.

Indexed as

cutaneous malignanciesdermatopathologydermoscopyoculocutaneous albinism

Identifiers

PMID32256696
PMCPMC7105334
OpenAlexW3007488897

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.