Evidence map›Paper›PMID 32256501›Full record

ReviewFrontiers in immunology2020

Adaptive Immunity in Pulmonary Sarcoidosis and Chronic Beryllium Disease.

Sarah A Greaves, Shaikh M Atif, Andrew P Fontenot

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

  1. Bioinformatics analysis identifies candidate biomarkers associated with sarcoidosis.Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG · 2025
    Article
  2. Article
  3. Article
  4. Review
  5. Sarcoidosis: a general overview.Advances in rheumatology (London, England) · 2024
    Review
  6. Article
  7. Article
  8. [The lungs: starting point for many diseases].Innere Medizin (Heidelberg, Germany) · 2023
    Review
  9. Article
  10. Innate and Adaptive Immunity in Noninfectious Granulomatous Lung Disease.Journal of immunology (Baltimore, Md. : 1950) · 2022
    Review
  11. Article
  12. Article
  13. T-Follicular Helper-like Cells in Sarcoidosis: Lending a Helping Hand.American journal of respiratory and critical care medicine · 2021
    Article
  14. Follicular Helper-like T Cells in the Lung Highlight a Novel Role of B Cells in Sarcoidosis.American journal of respiratory and critical care medicine · 2021
    Article
  15. Article
  16. Review
  17. Article
  18. Review
  19. Article
  20. Inflammatory Pathways in Sarcoidosis.Advances in experimental medicine and biology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sarah A GreavesDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Shaikh M AtifDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Andrew P FontenotDepartment of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
University of Colorado Anschutz Medical Campus · US

Funding

T cell epitopes in sarcoidosisR01HL136137 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI PALMER, BRENT E · 2017 to 2024
$4.7M
Role of Chemokines in Innate and Adaptive Immunity in the LungR01HL152756 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ATIF, SHAIKH M · 2020 to 2023
$2.4M
Interactions between antigen-specific effector and regulatory T cells in beryllium-induced diseaseR01ES025534 · NIEHS · UNIVERSITY OF COLORADO DENVER · PI FONTENOT, ANDREW P. · 2016 to 2020
$2.1M
Patient-Oriented Research in Immunologic Lung Disease.K24HL102245 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI FONTENOT, ANDREW P. · 2010 to 2020
$1.4M
NHLBI NIH HHS K24 HL102245NHLBI NIH HHS R01 HL136137NHLBI NIH HHS R01 HL152756NIEHS NIH HHS R01 ES025534
6 · The paper itself

Abstract

Pulmonary sarcoidosis and chronic beryllium disease (CBD) are inflammatory granulomatous lung diseases defined by the presence of non-caseating granulomas in the lung. CBD results from beryllium exposure in the workplace, while the cause of sarcoidosis remains unknown. CBD and sarcoidosis are both immune-mediated diseases that involve Th1-polarized inflammation in the lung. Beryllium exposure induces trafficking of dendritic cells to the lung in a mechanism dependent on MyD88 and IL-1α. B cells are also recruited to the lung in a MyD88 dependent manner after beryllium exposure in order to protect the lung from beryllium-induced injury. Similar to most immune-mediated diseases, disease susceptibility in CBD and sarcoidosis is driven by the expression of certain MHCII molecules, primarily

Indexed as

Adaptive ImmunityAnimalsBerylliosisChronic DiseaseHLA-DP beta-ChainsHumansLungSarcoidosis, PulmonaryT-LymphocytesT-Lymphocyte SubsetsHLA-DPB1 antigenHLA-DP beta-ChainshumanlungMHCsarcoidosisT cell receptorsT cells

Identifiers

PMID32256501
PMCPMC7093490
OpenAlexW3012288305

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.