Evidence map›Paper›PMID 32256389›Full record

ArticleFrontiers in physiology2020

Cardiovascular Remodeling Experienced by Real-World, Unsupervised, Young Novice Marathon Runners.

Andrew D'Silva, Anish N Bhuva, Jet van Zalen, Rachel Bastiaenen, Amna Abdel-Gadir, Siana Jones, Niromila Nadarajan, Katia D Menacho Medina, Yang Ye, Joao Augusto and 17 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  6. Review
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  9. Cardiovascular adaptations and inflammation in marathon runners.Experimental and therapeutic medicine · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 7 institutions in 3 countries.

Andrew D'SilvaCardiology Clinical and Academic Group, St George's, University of London, London, United Kingdom.
Anish N BhuvaInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Jet van ZalenDepartment of Cardiovascular Imaging, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.
Rachel BastiaenenDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Amna Abdel-GadirInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Siana JonesInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Niromila NadarajanInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Katia D Menacho MedinaInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Yang YeDepartment of Cardiology, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang University, Hangzhou, China.
Joao AugustoDepartment of Cardiovascular Imaging, Barts Heart Centre, St Bartholomew's Hospital, London, United Kingdom.
Thomas A TreibelInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Stefania RosminiInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Manish RamlallInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Paul R ScullyInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Camilla TorlascoDepartment of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Milan, Italy.
James WillisDepartment of Cardiology, Royal United Hospitals Bath NHS Foundation Trust, Bath, United Kingdom.
Gherardo FinocchiaroDepartment of Cardiology, Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom.
Efstathios PapatheodorouCardiology Clinical and Academic Group, St George's, University of London, London, United Kingdom.
Harshil DhutiaCardiology Clinical and Academic Group, St George's, University of London, London, United Kingdom.
Della ColeCardiology Clinical and Academic Group, St George's, University of London, London, United Kingdom.
Irina Chis SterInfection and Immunity Research Institute, St George's, University of London, London, United Kingdom.
Alun D HughesInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Rajan SharmaCardiology Clinical and Academic Group, St George's, University of London, London, United Kingdom.
Charlotte ManistyInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Guy LloydInstitute for Cardiovascular Science, University College London, London, United Kingdom.
James C MoonInstitute for Cardiovascular Science, University College London, London, United Kingdom.
Sanjay SharmaCardiology Clinical and Academic Group, St George's, University of London, London, United Kingdom.
University College London · GBSt George's, University of London · GBSt Bartholomew's Hospital · GBGuy's and St Thomas' NHS Foundation Trust · GBIRCCS Istituto Auxologico Italiano · ITRoyal United Hospital Bath NHS Trust · GBSir Run Run Shaw Hospital · CN

Funding

British Heart Foundation FS/15/27/31465British Heart Foundation FS/19/35/34374
6 · The paper itself

Abstract

aimsMarathon running is a popular ambition in modern societies inclusive of non-athletes. Previous studies have highlighted concerning transient myocardial dysfunction and biomarker release immediately after the race. Whether this method of increasing physical activity is beneficial or harmful remains a matter of debate. We examine in detail the real-world cardiovascular remodeling response following competition in a first marathon.

methodsSixty-eight novice marathon runners (36 men and 32 women) aged 30 ± 3 years were investigated 6 months before and 2 weeks after the 2016 London Marathon race in a prospective observational study. Evaluation included electrocardiography, cardiopulmonary exercise testing, echocardiography, and cardiovascular magnetic resonance imaging.

resultsAfter 17 weeks unsupervised marathon training, runners revealed a symmetrical, eccentric remodeling response with 3-5% increases in left and right ventricular cavity sizes, respectively. Blood pressure (BP) fell by 4/2 mmHg (

conclusionIn the absence of supervised training, exercise-induced cardiovascular remodeling in real-world novice marathon runners is more modest than previously described and occurs even without improvement in cardiorespiratory fitness. The responses are similar in men and women, who experience a beneficial BP reduction and no evidence of myocardial fibrosis or persistent edema, when achieving average finishing times.

Indexed as

athlete’s heartcardiorespiratory fitnesscardiovascular remodelingendurance exercisemarathonsports cardiology

Identifiers

PMID32256389
PMCPMC7093496
OpenAlexW3012234977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.