ArticleFrontiers in cellular neuroscience2020
Hebbian and Homeostatic Synaptic Plasticity-Do Alterations of One Reflect Enhancement of the Other?
Article in Frontiers in cellular neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Intracortical Microstimulation in Brain-Computer Interfaces: Evoking Perception and Plasticity.Cyborg and bionic systems (Washington, D.C.) · 2026Review
- Long-term potentiation and long-term depression are both impaired afterBiomedical physics & engineering express · 2025Article
- Control of Inhibition-Stabilized Oscillations in Wilson-Cowan Networks with Homeostatic Plasticity.Entropy (Basel, Switzerland) · 2025Article
- Exploring the microbiota-gut-brain axis: impact on brain structure and function.Frontiers in neuroanatomy · 2025Review
- TRPM2 and CaMKII Signaling Drives Excessive GABAergic Synaptic Inhibition Following Ischemia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Cell-type specific inhibitory plasticity in subicular pyramidal cells.Frontiers in cellular neuroscience · 2024Article
- Non-rapid eye movement sleep slow-wave activity features are associated with amyloid accumulation in older adults with obstructive sleep apnoea.Brain communications · 2024Article
- Quantum Biology and the Potential Role of Entanglement and Tunneling in Non-Targeted Effects of Ionizing Radiation: A Review and Proposed Model.International journal of molecular sciences · 2023Review
- Anxiety and depression: A top-down, bottom-up model of circuit function.Annals of the New York Academy of Sciences · 2023Review
- Hebbian and homeostatic synaptic plasticity of AMPA receptors in epileptogenesis.Cell reports. Medicine · 2023Article
- Inhibitory neurons control the consolidation of neural assemblies via adaptation to selective stimuli.Scientific reports · 2023Article
- c-Abl kinase at the crossroads of healthy synaptic remodeling and synaptic dysfunction in neurodegenerative diseases.Neural regeneration research · 2023Review
- Synapse Dysfunctions in Multiple Sclerosis.International journal of molecular sciences · 2023Review
- miR-124-dependent tagging of synapses by synaptopodin enables input-specific homeostatic plasticity.The EMBO journal · 2022Article
- Postsynaptic Potential Energy as Determinant of Synaptic Plasticity.Frontiers in computational neuroscience · 2022Article
- Alterations of the Hippocampal Networks in Valproic Acid-Induced Rat Autism Model.Frontiers in neural circuits · 2022Article
- Aberrant maturation and connectivity of prefrontal cortex in schizophrenia-contribution of NMDA receptor development and hypofunction.Molecular psychiatry · 2022Review
- Dosing Transcranial Magnetic Stimulation of the Primary Motor and Dorsolateral Prefrontal Cortices With Multi-Scale Modeling.Frontiers in neuroscience · 2022Article
- The Yin and Yang of GABAergic and Glutamatergic Synaptic Plasticity: Opposites in Balance by Crosstalking Mechanisms.Frontiers in synaptic neuroscience · 2022Review
- Phosphorylation of the AMPA receptor subunit GluA1 regulates clathrin-mediated receptor internalization.Journal of cell science · 2021Article
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2 authors.
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Abstract
During the past 50 years, the cellular and molecular mechanisms of synaptic plasticity have been studied in great detail. A plethora of signaling pathways have been identified that account for synaptic changes based on positive and negative feedback mechanisms. Yet, the biological significance of Hebbian synaptic plasticity (= positive feedback) and homeostatic synaptic plasticity (= negative feedback) remains a matter of debate. Specifically, it is unclear how these opposing forms of plasticity, which share common downstream mechanisms, operate in the same networks, neurons, and synapses. Based on the observation that rapid and input-specific homeostatic mechanisms exist, we here discuss a model that is based on signaling pathways that may adjust a balance between Hebbian and homeostatic synaptic plasticity. Hence, "alterations" in Hebbian plasticity may, in fact, resemble "enhanced" homeostasis, which rapidly returns synaptic strength to baseline. In turn, long-lasting experience-dependent synaptic changes may require attenuation of homeostatic mechanisms or the adjustment of homeostatic setpoints at the single-synapse level. In this context, we propose a role for the proteolytic processing of the amyloid precursor protein (APP) in setting a balance between the ability of neurons to express Hebbian and homeostatic synaptic plasticity.
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