ArticleFrontiers in neuroscience2020
Novel Opioids: Systematic Web Crawling Within the e-Psychonauts' Scenario.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- NPS detection in prison: A systematic literature review of use, drug form, and analytical approaches.Drug testing and analysis · 2022Pooled it
- Novel Synthetic Opioids (NSOs) and Their Evolving Crisis: Utilising NPSPharmaceuticals (Basel, Switzerland) · 2025Article
- The risk of developing more potent fentanyl analogs: a mini review.Frontiers in pharmacology · 2025Review
- Novel Synthetic Opioids (NSO) Use in Opioid Dependents Entering Detoxification Treatment.Frontiers in psychiatry · 2022Article
- The Psychonauts' Benzodiazepines; Quantitative Structure-Activity Relationship (QSAR) Analysis and Docking Prediction of Their Biological Activity.Pharmaceuticals (Basel, Switzerland) · 2021Article
- COVID-19 Pandemic Impact on Substance Misuse: A Social Media Listening, Mixed Method Analysis.Brain sciences · 2021Article
- Availability of Illegal Drugs During the COVID-19 Pandemic in Western Germany.Frontiers in psychiatry · 2021Article
- Adolescent Substance Abuse, Transgenerational Consequences and Epigenetics.Current neuropharmacology · 2021Article
- In vitro functional characterization of a panel of non-fentanyl opioid new psychoactive substances.Archives of toxicology · 2020Article
- Analyzing the Open/Deep Web to Better Understand the New/Novel Psychoactive Substances (NPS) Scenarios: Suggestions from CASSANDRA and NPS.Finder Research Projects.Brain sciences · 2020Article
- Identifying New/Emerging Psychoactive Substances at the Time of COVID-19; A Web-Based Approach.Frontiers in psychiatry · 2020Article
- The Psychonauts' World of Cognitive Enhancers.Frontiers in psychiatry · 2020Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundA wide range of novel psychoactive substances (NPSs) are regularly searched and discussed online by e-psychonauts. Among NPSs, the range of prescription/non-prescription opioids (fentanyl and non-fentanyl analogs) and herbal derivatives currently represents a challenge for governments and clinicians.
methodsUsing a web crawler (i.e., NPS.Finder
resultsThe open-web crawling/navigating software identified some 426 opioids, including 234 fentanyl analogs. Of these, 176 substances (162 were very potent fentanyls, including two ohmefentanyl and seven carfentanyl analogs) were not listed in either international or European NPS databases.
conclusionA web crawling approach helped in identifying a large number, indeed higher than that listed by European/international agencies, of unknown opioids likely to possess a significant misuse potential. Most of these novel/emerging substances are still relatively unknown. This is a reason of concern; each of these analogs potentially presents with different toxicodynamic profiles, and there is a lack of docking, preclinical, and clinical observations. Strengthening multidisciplinary collaboration between clinicians and bioinformatics may prove useful in better assessing public health risks associated with opioids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.