Evidence map›Paper›PMID 32256277›Full record

ArticleAdvanced functional materials2019

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury.

Teng Su, Ke Huang, Hong Ma, Hongxia Liang, Phuong-Uyen Dinh, Justin Chen, Deliang Shen, Tyler A Allen, Li Qiao, Zhenhua Li and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced functional materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
91citing papers in PubMed, 1 pooled it
5.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

91 citing papers in PubMed, 1 synthesis or guideline pooled it, 159 citations in OpenAlex.

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  13. A BACH1 inhibitor ameliorates myocardial infarction and limb ischemia in mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2025
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31 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 3 institutions in 2 countries.

Teng Su *Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North, Carolina State University, Raleigh, NC 27695, USA.
Ke Huang *Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North, Carolina State University, Raleigh, NC 27695, USA.
Hong Ma *Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Hongxia LiangDepartment of Molecular Biomedical Sciences and Comparative, Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Phuong-Uyen DinhDepartment of Molecular Biomedical Sciences and Comparative, Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Justin ChenJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North, Carolina State University, Raleigh, NC 27695, USA.
Deliang ShenDepartment of Cardiology, The First Affiliated Hospital of Zhengzhou University Zhengzhou, Henan 450052, China.
Tyler A AllenDepartment of Molecular Biomedical Sciences and Comparative, Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Li QiaoDepartment of Molecular Biomedical Sciences and Comparative, Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Zhenhua LiDepartment of Molecular Biomedical Sciences and Comparative, Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Shiqi HuDepartment of Molecular Biomedical Sciences and Comparative, Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Jhon CoresJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North, Carolina State University, Raleigh, NC 27695, USA.
Brianna N FrameDivision of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Ashlyn T YoungJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North, Carolina State University, Raleigh, NC 27695, USA.
Qi YinDepartment of Molecular Biomedical Sciences and Comparative, Medicine Institute, North Carolina State University, Raleigh, NC 27607, USA.
Jiandong LiuDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Li QianDepartment of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Thomas G CaranasosDivision of Cardiothoracic Surgery, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Yevgeny BrudnoJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North, Carolina State University, Raleigh, NC 27695, USA.
Frances S LiglerJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North, Carolina State University, Raleigh, NC 27695, USA.
Ke ChengJoint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North, Carolina State University, Raleigh, NC 27695, USA.
University of North Carolina at Chapel Hill · USNorth Carolina State University · USHebei Medical University · CN

Funding

Targeted Nanoparticles for Stem Cell Redirecting and Regenerative MedicineR01HL123920 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CHENG, KE · 2015 to 2023
$4.8M
Enhancing vascular delivery of stem cells and microparticlesR01HL137093 · NHLBI · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI CHENG, KE · 2017 to 2020
$1.5M
NHLBI NIH HHS R01 HL123920NHLBI NIH HHS R01 HL137093
6 · The paper itself

Abstract

Cardiovascular disease is the leading cause of mortality worldwide. While reperfusion therapy is vital for patient survival post-heart attack, it also causes further tissue injury, known as myocardial ischemia/reperfusion (I/R) injury in clinical practice. Exploring ways to attenuate I/R injury is of clinical interest for improving post-ischemic recovery. A platelet-inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE

Indexed as

biomimeticsdrug deliveryischemic injuryplateletsstromal cell secretome

Identifiers

PMID32256277
PMCPMC7111457
OpenAlexW2900656286

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.