Evidence map›Paper›PMID 32256216›Full record

ArticleThrombosis journal2020

Changes in anticoagulant prescription in Dutch patients with recent-onset atrial fibrillation: observations from the GARFIELD-AF registry.

J Seelig, F W A Verheugt, M E W Hemels, L Illingworth, A Lucassen, H Adriaansen, M C M Bongaerts, M Pieterse, J P R Herrman, P Hoogslag and 6 more

Open access · goldAbstract read
In one paragraph

Article in Thrombosis journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Prescription patterns of direct oral anticoagulants and concomitant use of interacting medications in the Netherlands.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2021
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 10 institutions in 3 countries.

J Seelig1Department of Cardiology, Rijnstate, Wagnerlaan 55, 6815 AD Arnhem, the Netherlands.
F W A Verheugt2Department of Cardiology, Onze Lieve Vrouwe Gasthuis (OLVG), Amsterdam, the Netherlands.
M E W Hemels1Department of Cardiology, Rijnstate, Wagnerlaan 55, 6815 AD Arnhem, the Netherlands.
L Illingworth4Thrombosis Research Institute, London, UK.
A LucassenDepartment of Cardiology, St. Jans Gasthuis, Weert, the Netherlands.
H Adriaansen6Anticoagulation Clinic, Gelre Ziekenhuizen, Apeldoorn-Zutphen, the Netherlands.
M C M Bongaerts7Anticoagulation Clinic, Ziekenhuis Rivierenland, Tiel, the Netherlands.
M PieterseStichting Cardiologie Amsterdam, Amsterdam, the Netherlands.
J P R Herrman9Department of Cardiology, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands.
P HoogslagDepartment of Cardiology, Isala Diaconessenhuis, Meppel, the Netherlands.
W Hermans11Department of Cardiology, Elisabeth-TweeSteden Ziekenhuis, Tilburg, the Netherlands.
B E Groenemeijer12Department of Cardiology, Gelre Ziekenhuizen, Apeldoorn, the Netherlands.
L V A Boersma13Department of Cardiology, St. Antonius Ziekenhuis, Nieuwegein, the Netherlands.
K Pieper4Thrombosis Research Institute, London, UK.
H Ten Cate16Department of Internal Medicine, Cardiovascular Research Institute Maastricht, Maastricht, the Netherlands.
GARFIELD-AF Investigators
Gelre Hospitals · NLMaastricht School of Management · NLOLVG · NLRadboud University Nijmegen · NLClinical Research Institute · USIsala · NLMaastricht University · NLRijnstate Hospital · NLSt.Jans Gasthuis Weert · NLZiekenhuis Rivierenland · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFor the improvement of AF care, it is important to gain insight into current anticoagulation prescription practices and guideline adherence. This report focuses on the largest Dutch subset of AF-patients, derived from the GARFIELD-AF registry.

methodsAcross 35 countries worldwide, patients with newly diagnosed 'non-valvular' atrial fibrillation (AF) with at least one additional risk factor for stroke were included. Dutch patients were enrolled in five, independent, consecutive cohorts from 2010 until 2016.

resultsIn the Netherlands, 1189 AF-patients were enrolled. The prescription of non-vitamin K antagonist oral anticoagulants (NOAC) has increased sharply, and as per 2016, more patients were initiated on NOACs instead of vitamin K antagonists (VKA). In patients with a class I recommendation for anticoagulation, only 7.5% compared to 30.0% globally received no anticoagulation. Reasons for withholding anticoagulation in these patients were unfortunately often unclear.

conclusionsThe data from the GARFIELD-AF registry shows the rapidly changing anticoagulation preference of Dutch physicians in newly diagnosed AF. Adherence to European AF guidelines in terms of anticoagulant regimen would appear to be appropriate. In absence of structured follow up of AF patients on NOAC, the impact of these rapid practice changes in anticoagulation prescription in the Netherlands remains to be established.

Indexed as

AnticoagulantsAtrial fibrillationGuideline adherenceInappropriate prescribing

Identifiers

PMID32256216
PMCPMC7104512
OpenAlexW3015187255

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.