Evidence map›Paper›PMID 32256196›Full record

ArticleMediators of inflammation2020

Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers.

Alexander Hedbrant, Lena Andersson, Ing-Liss Bryngelsson, Daniel Eklund, Håkan Westberg, Eva Särndahl, Alexander Persson

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 24 citations in OpenAlex.

  1. Review
  2. Review
  3. The prevalence of respiratory symptoms and diseases and declined lung function among foundry workers.Journal of occupational medicine and toxicology (London, England) · 2024
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Environmental Triggers of Hyperuricemia and Gout.Rheumatic diseases clinics of North America · 2022
    Review
  9. Review
  10. Review
  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Alexander HedbrantDepartment of Medical Sciences, School of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden.ORCID https://orcid.org/0000-0001-7634-5302
Lena AnderssonDepartment of Occupational and Environmental Medicine, Örebro University Hospital, SE-701 85 Örebro, Sweden.
Ing-Liss BryngelssonDepartment of Occupational and Environmental Medicine, Örebro University Hospital, SE-701 85 Örebro, Sweden.
Daniel EklundDepartment of Medical Sciences, School of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden.ORCID https://orcid.org/0000-0002-6045-4800
Håkan WestbergDepartment of Medical Sciences, School of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden.
Eva SärndahlDepartment of Medical Sciences, School of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden.ORCID https://orcid.org/0000-0002-4319-7208
Alexander PerssonDepartment of Medical Sciences, School of Medicine and Health, Örebro University, SE-701 82 Örebro, Sweden.ORCID https://orcid.org/0000-0002-9631-2169
Örebro University · SEÖrebro University Hospital · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo study the association between inhalation of particulate matter or quartz in Swedish iron foundries and the effects on NLRP3 inflammasome activation.

methodsParticle exposure measurements were performed during an eight-hour work day for 85 foundry workers at three Swedish iron foundries. Personal sampling was used for measurement of respirable quartz and dust and stationary measurements to obtain exposure measurements for inhalable dust and PM

resultsThe average exposure levels of respirable dust and quartz were 0.85 and 0.052 mg/m

conclusionsThe results indicate that exposure levels of PM in the iron foundry environment can affect the NLRP3 inflammasome and systemic inflammation.

Indexed as

AdultCARD Signaling Adaptor ProteinsCaspase 1FemaleHumansInflammasomesInterleukin-18Interleukin-1betaInterleukin 1 Receptor Antagonist ProteinMaleMiddle AgedNeoplasm ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinPolymorphism, Single NucleotideCARD8 protein, humanCARD Signaling Adaptor ProteinsCaspase 1InflammasomesInterleukin-18Interleukin-1betaInterleukin 1 Receptor Antagonist ProteinNeoplasm ProteinsNLR Family, Pyrin Domain-Containing 3 ProteinNLRP3 protein, human

Identifiers

PMID32256196
PMCPMC7091550
OpenAlexW2999044234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.