Evidence map›Paper›PMID 32256060›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2020

Evaluating Patient Preferences of Maintenance Therapy for the Treatment of Chronic Obstructive Pulmonary Disease: A Discrete Choice Experiment in the UK, USA and Germany.

Hannah B Lewis, Melanie Schroeder, Necdet B Gunsoy, Ellen M Janssen, Samuel Llewellyn, Helen A Doll, Paul W Jones, Afisi S Ismaila

Abstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Cost-Effectiveness of Once-Daily Single-Inhaler COPD Triple Therapy in Spain: IMPACT Trial.International journal of chronic obstructive pulmonary disease · 2022
    Trial
  4. Article
  5. Article
  6. Article
  7. Review
  8. INTREPID: single-ERJ open research · 2021
    Article
  9. Article
  10. Cost-Effectiveness Of Once-Daily Single-Inhaler Triple Therapy In COPD: The IMPACT Trial.International journal of chronic obstructive pulmonary disease · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hannah B LewisPatient Centred Outcomes, ICON plc., London, UK.
Melanie SchroederValue Evidence and Outcomes, GlaxoSmithKline plc., Brentford, UK.ORCID 0000-0003-0338-1331
Necdet B GunsoyValue Evidence and Outcomes, GlaxoSmithKline plc., Uxbridge, UK.
Ellen M JanssenPatient Centred Outcomes, ICON plc., Gaithersburg, MD, USA.
Samuel LlewellynPatient Centred Outcomes, ICON plc., Abingdon, UK.
Helen A DollPatient Centred Outcomes, ICON plc., London, UK.ORCID 0000-0002-1871-8710
Paul W JonesRespiratory Therapy Area, GlaxoSmithKline plc., Brentford, UK.ORCID 0000-0001-6087-9182
Afisi S IsmailaValue Evidence and Outcomes, GlaxoSmithKline plc., Collegeville, PA, USA.ORCID 0000-0002-2876-8308

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: With increasing availability of different treatments for chronic obstructive pulmonary disease (COPD), we sought to understand patient preferences for COPD treatment in the UK, USA, and Germany using a discrete choice experiment (DCE). Methods: Qualitative research identified six attributes associated with COPD maintenance treatments: ease of inhaler use, exacerbation frequency, frequency of inhaler use, number of different inhalers used, side effect frequency, and out-of-pocket costs. A DCE using these attributes, with three levels each, was designed and tested through cognitive interviews and piloting. It comprised 18 choice sets, selected using a D-efficient experimental design. Demographics and disease history were collected and the final DCE survey was completed online by participants recruited from panels in the UK, USA and Germany. Responses were analyzed using mixed logit models, with results expressed as odds ratios (ORs). Results: Overall, 450 participants (150 per country) completed the DCE; most (UK and Germany, 97.3%; USA, 98.0%) were included in the final analysis. Based on relative attribute importance, avoidance of side effects was found to be most important (UK: OR 11.65; USA: OR 7.17; Germany: OR 11.45; all Conclusion: When selecting COPD treatment, individuals assigned the highest value to the avoidance of side effects, experiencing fewer exacerbations, and ease of inhaler use. Ensuring that patients' preferences are considered may encourage treatment compliance.

Indexed as

Patient PreferencePulmonary Disease, Chronic ObstructiveGermanyHumansNebulizers and VaporizersUnited KingdomCOPDDCEdiscrete choice experimentstated-preference methodssymptomatic chronic obstructive pulmonary disease

Identifiers

PMID32256060
PMCPMC7094150

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.