ReviewClinical ophthalmology (Auckland, N.Z.)2020
Pathogenesis and Prevention of Worsening Axial Elongation in Pathological Myopia.
Review in Clinical ophthalmology (Auckland, N.Z.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Efficacy of spectacle lenses specifically designed for myopia control: systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- Control of myopia using diffusion optics spectacle lenses: 12-month results of a randomised controlled, efficacy and safety study (CYPRESS).The British journal of ophthalmology · 2023Trial
- Three-Year Visual Quality Evaluation in Children Using Orthokeratology Lenses: A Retrospective Study With OPD-Scan III Measurements.Journal of ophthalmology · 2026Article
- Real-World Validation of the VIVEX Formula for Vitreous Volume Estimation in Vitreoretinal Surgery: A First Clinical Case Series.Ophthalmology and therapy · 2026Article
- Choroidal Structural and Vascular Changes During Myopia Progression and in Response to Myopia Control Interventions: A Systematic Review.Clinical ophthalmology (Auckland, N.Z.) · 2026Review
- Impact of the COVID-19 pandemic lockdowns on manifest refraction in a young adult population: A large cohort study.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Observational
- Clinical characteristics and risk factors of ocular hypertension: a case-control study.BMC ophthalmology · 2025Article
- Age-Related Regional Changes in Choroidal Vascularity in Healthy Emmetropic Eyes.Translational vision science & technology · 2025Article
- Identifying pathological myopia associated genes with GenePlexus in protein-protein interaction network.Frontiers in genetics · 2025Article
- Investigation into the Therapeutic Efficacy and Inflammatory Modulatory Effects of the Combined Use of 0.01% Atropine Eye Drops and Orthokeratology Lenses in the Management of Myopia Among Adolescent Patients.Journal of inflammation research · 2025Article
- AI-based fully automatic analysis of retinal vascular morphology in pediatric high myopia.BMC ophthalmology · 2024Article
- Retardation of myopia by atropine regimes.International journal of ophthalmology · 2024Review
- Molecular Basis of Transglutaminase-2 and Muscarinic Cholinergic Receptors in Experimental Myopia: A Target for Myopia Treatment.Biomolecules · 2023Article
- Microvascular Alterations of Peripapillary Choriocapillaris in Young Adult High Myopia Detected by Optical Coherence Tomography Angiography.Journal of personalized medicine · 2023Article
- Machine learning predicting myopic regression after corneal refractive surgery using preoperative data and fundus photography.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2022Article
- The Impact of the COVID-19 Pandemic on Myopia Progression in Children: A Systematic Review.Cureus · 2022Review
- Choroidal Thickness in Correlation with Axial Length and Myopia Degree.Vision (Basel, Switzerland) · 2022Article
- Dioptric power and refractive behaviour: a review of methods and applications.BMJ open ophthalmology · 2022Review
- Regional analysis of segmented-macular structure in patients with myopic anisometropia.International ophthalmology · 2021Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThis review discusses the etiology and pathogenesis of myopia, prevention of disease progression and worsening axial elongation, and emerging myopia treatment modalities.
introductionPediatric myopia is a public health concern that impacts young children worldwide and is associated with numerous future ocular diseases such as cataract, glaucoma, retinal detachment and other chorioretinal abnormalities. While the exact mechanism of myopia of the human eye remains obscure, several studies have reported on the role of environmental and genetic factors in the disease development.
methodsA review of literature was conducted. PubMed and Medline were searched for combinations and derivatives of the keywords including, but not limited to, "pediatric myopia", "axial elongation", "scleral remodeling" or "atropine." The PubMed and Medline database search were performed for randomized control trials, systematic reviews and meta-analyses using the same keyword combinations.
resultsStudies have reported that detection of genetic correlations and modification of environmental influences may have a significant impact in myopia progression, axial elongation and future myopic ocular complications. The conventional pharmacotherapy of pediatric myopia addresses the improvement in visual acuity and prevention of amblyopia but does not affect axial elongation or myopia progression. Several studies have published varying treatments, including optical, pharmacological and surgical management, which show great promise for a more precise control of myopia and preservation of ocular health. DISCUSSION: Understanding the role of factors influencing the onset and progression of pediatric myopia will facilitate the development of successful treatments, reduction of disease burden, arrest of progression and improvement in future of the management of myopia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.