Evidence map›Paper›PMID 32256019›Full record

ArticleWorld journal of gastroenterology2020

Qingyi decoction protects against myocardial injuries induced by severe acute pancreatitis.

Lei Li, Yong-Qi Li, Zhong-Wei Sun, Cai-Ming Xu, Jun Wu, Ge-Liang Liu, Ahmed Mh Bakheet, Hai-Long Chen

Open access · bronzeAbstract read
In one paragraph

Article in World journal of gastroenterology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

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  13. Pyroptosis in acute pancreatitis and its therapeutic regulation.Apoptosis : an international journal on programmed cell death · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Lei LiDepartment of Vascular Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China.
Yong-Qi LiGraduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 3058575, Japan.
Zhong-Wei SunDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
Cai-Ming XuDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China.
Jun WuDepartment of Ultrasound, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China.
Ge-Liang LiuDepartment of Urology Surgery, The Second Affiliated Hospital of Dalian Medical University, Dalian 116027, Liaoning Province, China.
Ahmed Mh BakheetDepartment of Pathology, The Third Affiliated Hospital of San Yet-sen University, Guangzhou 510360, Guangdong Province, China.
Hai-Long ChenDepartment of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian 116011, Liaoning Province, China. hailongchen2018@163.com.
Dalian Medical University · CNSecond Affiliated Hospital of Dalian Medical University · CNSun Yat-sen University · CNUniversity of Tsukuba · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe studied the protective effects of Qingyi decoction (QYD) (a Traditional Chinese Medicine) against severe acute pancreatitis (SAP)-induced myocardial infarction (MI).

aimTo study the function and mechanism of QYD in the treatment of myocardial injuries induced by SAP.

methodsUltrasonic cardiography, hematoxylin and eosin staining, immunohistochemistry, qRT-PCR, western blot, enzyme-linked immunosorbent assays, and apoptosis staining techniques were used to determine the effects of QYD following SAP-induced MI in Sprague-Dawley rats.

resultsOur SAP model showed severe myocardial histological abnormalities and marked differences in the symptoms, mortality rate, and ultrasonic cardiography outputs among the different groups compared to the control. The expression of serum cytokines [interleukin (IL)-1ß, IL-6, IL-8, IL-12, amyloid β, and tumor necrosis factor-α] were significantly higher in the SAP versus QYD treated group (

conclusionQYD conferred cardio-protection against SAP-induced MI by regulating myocardial-associated protein expression (STIM1 and Orai1).

Indexed as

Acute DiseaseAnimalsCytokinesDisease Models, AnimalDrugs, Chinese HerbalHeart InjuriesMaleMyocardiumORAI1 ProteinPancreatitisProtective AgentsRatsRats, Sprague-DawleyStromal Interaction Molecule 1CytokinesDrugs, Chinese HerbalORAI1 ProteinProtective AgentsqingyiStromal Interaction Molecule 1Multiple organ dysfunctionMyocardial injuryQingyi decoctionSevere acute pancreatitisSTIM1/Orai1-SOCE

Identifiers

PMID32256019
PMCPMC7109276
OpenAlexW3013585106

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.