ArticleProceedings of SPIE--the International Society for Optical Engineering2016
Visualizing Oxazine 4 nerve-specific fluorescence
Article in Proceedings of SPIE--the International Society for Optical Engineering, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Intraoperative nerve-specific fluorescence visualization in head and neck surgery: a Phase 1 trial.Nature communications · 2025Article
- A robotic system for automated chemical synthesis of therapeutic agents.Materials advances · 2024Article
- Advances in optical molecular imaging for neural visualization.Frontiers in bioengineering and biotechnology · 2023Review
- Cytotoxicity analysis of oxazine 4-perchlorate fluorescence nerve potential clinical biomarker for guided surgery.Biomedical optics express · 2022Article
- Intraoperative molecular imaging clinical trials: a review of 2020 conference proceedings.Journal of biomedical optics · 2021Review
- In Vivo Nerve-Specificity of Rhodamines and Si-rhodamines.Proceedings of SPIE--the International Society for Optical Engineering · 2020Article
- Investigation of Oxazine and Rhodamine Derivatives as Peripheral Nerve Tissue Targeting Contrast Agent forProceedings of SPIE--the International Society for Optical Engineering · 2019Article
- Nile Red derivatives enable improved ratiometric imaging for nerve-specific contrast.Journal of biomedical optics · 2018Article
- Optimizing fresh specimen staining for rapid identification of tumor biomarkers during surgery.Theranostics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Nerve damage plagues surgical outcomes and remains a major burden for patients, surgeons, and the healthcare system. Fluorescence image-guided surgery using nerve specific small molecule fluorophores offers a solution to diminish surgical nerve damage through improved intraoperative nerve identification and visualization. Oxazine 4 has shown superior nerve specificity in initial testing
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.