Evidence map›Paper›PMID 32255772›Full record

ArticlePloS one2020

Community based reference interval of selected clinical chemistry parameters among apparently healthy Adolescents in Mekelle City, Tigrai, Northern Ethiopia.

Getachew Belay, Gebreyohanes Teklehaymanot, Gebreslassie Gebremariam, Kelali Kaleaye, Hagos Haileslasie, Gebremedhin Gebremichail, Brhane Tesfanchal, Getachew Kahsu, Brhane Berhe, Kebede Tesfay and 4 more

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Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

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0cells of the map it votes in
4citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Getachew BelayUnit of Clinical Chemistry, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.ORCID 0000-0002-9750-527X
Gebreyohanes TeklehaymanotUnit of Hematology and Immuno-Hematology, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Mekelle University, Mekelle, Ethiopia.
Gebreslassie GebremariamUnit of Clinical Chemistry, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Mekelle University, Mekelle, Ethiopia.
Kelali KaleayeLaboratory Diagnostic, Research and Quality Assurance Directorate, Tigrai Health Research Institute, Mekelle, Ethiopia.
Hagos HaileslasieUnit of Hematology and Immuno-Hematology, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.
Gebremedhin GebremichailUnit of Hematology and Immuno-Hematology, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.
Brhane TesfanchalUnit of Clinical Chemistry, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.
Getachew KahsuUnit of Clinical Chemistry, Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia.
Brhane BerheUnit of Medical Parasitology and Entomology, Department of Medical Laboratory Science, College of Medcine and Health Science, Adigrat University, Adigrat, Ethiopia.
Kebede TesfayUnit of Medical Parasitology and Entomology, Department of Medical Laboratory Science, College of Medcine and Health Science, Adigrat University, Adigrat, Ethiopia.
Lemlem LegesseLaboratory Diagnostic, Research and Quality Assurance Directorate, Tigrai Health Research Institute, Mekelle, Ethiopia.
Ataklti GebretsadikLaboratory Diagnostic, Research and Quality Assurance Directorate, Tigrai Health Research Institute, Mekelle, Ethiopia.
Mistire WoldeDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.
Aster TsegayeDepartment of Medical Laboratory Sciences, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia.ORCID 0000-0002-9026-4629

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLocally established clinical laboratory reference intervals (RIs) are required to interpret laboratory test results for screening, diagnosis and prognosis. The objective of this study was establishing reference interval of clinical chemistry parameters among apparently healthy adolescents aged between 12 and 17 years in Mekelle, Tigrai, northern part of Ethiopia.

methodsCommunity based cross sectional study was employed from December 2018 to March 2019 in Mekelle city among 172 males and 172 females based on Multi stage sampling technique. Blood samples were tested for Fasting blood sugar (FBS), alanine aminino transferase (ALT), aspartate amino transferase (AST), alkaline phosphatase (ALP), Creatinine, urea, total protein, albumin (ALB), direct and indirect bilirubin (BIL.D and BIL.T) using 25 Bio system clinical chemistry analyzer. Results were analyzed using SPSS version 23 software and based on the Clinical Laboratory Standard Institute (CLSI)/ International Federation of Clinical Chemistry (IFCC) C 28-A3 Guideline which defines the reference interval as the 95% central range of 2.5th and 97.5th percentiles. Mann Whitney U test, descriptive statistics and box and whisker were statistical tools used for analysis.

resultsThis study observed statistically significant differences between males and females in ALP, ALT, AST, Urea and Creatinine Reference intervals. The established reference intervals for males and females, respectively, were: ALP (U/L) 79.48-492.12 versus 63.56-253.34, ALT (U/L) 4.54-23.69 versus 5.1-20.03, AST 15.7-39.1 versus 13.3-28.5, Urea (mg/dL) 9.33-24.99 versus 7.43-23.11, and Creatinine (mg/dL) 0.393-0.957 versus 0.301-0.846. The combined RIs for Total Protein (g/dL) was 6.08-7.85, ALB (g/dL) 4.42-5.46, FBS(mg/dL) 65-110, BIL.D (mg/dL) 0.033-0.532, and BIL.T (mg/dL) 0.106-0.812.

conclusionsThe result showed marked difference among sex and with the company derived values for selected clinical chemistry parameters. Thus, use of age and sex specific locally established reference intervals for clinical chemistry parameters is recommended.

Indexed as

AdolescentAlanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesBilirubinBlood GlucoseBlood ProteinsChemistry, ClinicalChildCreatinineCross-Sectional StudiesEthiopiaFemaleHumansMaleReference ValuesAlanine TransaminaseAlkaline PhosphataseAspartate AminotransferasesBilirubinBlood GlucoseBlood ProteinsCreatinineSerum AlbuminUrea

Identifiers

PMID32255772
PMCPMC7138298

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.