Evidence map›Paper›PMID 32255762›Full record

ArticleAging2020

Systemic administration of the di-apocarotenoid norbixin (BIO201) is neuroprotective, preserves photoreceptor function and inhibits A2E and lipofuscin accumulation in animal models of age-related macular degeneration and Stargardt disease.

Valérie Fontaine, Elodie Monteiro, Mylène Fournié, Elena Brazhnikova, Thinhinane Boumedine, Cécile Vidal, Christine Balducci, Louis Guibout, Mathilde Latil, Pierre J Dilda and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Valérie FontaineSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
Elodie MonteiroSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
Mylène FourniéSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
Elena BrazhnikovaSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
Thinhinane BoumedineSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
Cécile VidalSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
Christine BalducciBiophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
Louis GuiboutBiophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
Mathilde LatilBiophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
Pierre J DildaBiophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
Stanislas VeilletBiophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
José-Alain SahelSorbonne Université, INSERM, CNRS, Institut de la Vision, Paris 75012, France.
René LafontBiophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
Serge CameloBiophytis, Sorbonne Université, Campus Pierre and Marie Curie, Paris 75005, France.
Biophytis (France) · FRCentre National de la Recherche Scientifique · FRInstitut de la Vision · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atrophic A\age-related macular degeneration (AMD) and Stargardt disease (STGD) are major blinding diseases affecting millions of patients worldwide, but no treatment is available. In dry AMD and STGD oxidative stress and subretinal accumulation of

Indexed as

Macular DegenerationPhotoreceptor Cells, VertebrateRetinoidsStargardt DiseaseAnimalsCarotenoidsDrug MonitoringElectroretinographyInjections, IntraperitonealMiceNeuroprotective AgentsTreatment OutcomeA2-E (N-retinylidene-N-retinylethanolamine)CarotenoidsNeuroprotective AgentsnorbixinRetinoidsA2EAMDnorbixinretinal functionStargardt disease

Identifiers

PMID32255762
PMCPMC7185133
OpenAlexW3014968447

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.