Evidence map›Paper›PMID 32255672›Full record

ArticleAmerican journal of respiratory and critical care medicine2020

Functional Genomics of the Pediatric Obese Asthma Phenotype Reveal Enrichment of Rho-GTPase Pathways.

Deepa Rastogi, Andrew D Johnston, John Nico, Lip Nam Loh, Yurydia Jorge, Masako Suzuki, Fernando Macian, John M Greally

Open access · greenAbstract readComparative Study
In one paragraph

Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

  1. Differential gene expression in nasal airway epithelium from overweight or obese youth with asthma.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Pooled it
  2. Review
  3. Article
  4. Non-T2 asthma.Current opinion in pulmonary medicine · 2025
    Review
  5. Distinct single-cell transcriptional profile in CD4+ T-lymphocytes among obese children with asthma.American journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Interplay between Immune and Airway Smooth Muscle Cells in Obese Asthma.American journal of respiratory and critical care medicine · 2023
    Article
  14. Crosstalk between CD4American journal of respiratory and critical care medicine · 2023
    Article
  15. Obesity-related asthma in children and adolescents.The Lancet. Child & adolescent health · 2022
    Review
  16. Article
  17. Article
  18. Update in Pediatrics 2020.American journal of respiratory and critical care medicine · 2021
    Article
  19. The impact of obesity on immune function in pediatric asthma.Current opinion in allergy and clinical immunology · 2021
    Review
  20. A Role for the Rho-GTPase Pathway in Pediatric Obese Asthma.American journal of respiratory and critical care medicine · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Deepa RastogiDepartment of Pediatrics.ORCID 0000-0001-5714-9250
Andrew D JohnstonDepartment of Genetics, Albert Einstein College of Medicine, New York, New York.
John NicoDepartment of Pediatrics.
Lip Nam LohDepartment of Pediatrics.
Yurydia JorgeDepartment of Pediatrics.
Masako SuzukiDepartment of Genetics, Albert Einstein College of Medicine, New York, New York.
Fernando MacianDepartment of Pathology, and.
John M GreallyDepartment of Genetics, Albert Einstein College of Medicine, New York, New York.
Albert Einstein College of Medicine · US

Funding

UNDERSTANDING CELLULAR AND TRANSCRIPTIONAL REGULATORY CHANGES IN HUMAN AGINGR01AG057422 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI GREALLY, JOHN, LAPPALAINEN, TUULI · 2018 to 2022
$4.5M
Investigating the CDC42 pathway as a novel pathway for pediatric non-atopic obesity-related asthmaR01HL141849 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI RASTOGI, DEEPA · 2019 to 2023
$2.4M
Genetic and Epigenetic Determinants of Pediatric Obesity-Associated AsthmaK23HL118733 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI RASTOGI, DEEPA · 2014 to 2018
$893k
NHLBI NIH HHS K23 HL118733NHLBI NIH HHS R01 HL141849NIA NIH HHS R01 AG057422
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

GenomicsPhenotypeAdolescentAsthmaBlack or African AmericanChildChild, PreschoolFemaleGTPase-Activating ProteinsHealthy VolunteersHispanic or LatinoHumansInfantMalePediatric ObesityrhoA GTP-Binding ProteinARHGAP10 protein, humanGTPase-Activating ProteinsrhoA GTP-Binding ProteinchildrenDNA methylationexpression and methylation quantitative trait locigene expressionobesity-related asthma

Identifiers

PMID32255672
PMCPMC7365356
OpenAlexW3014828313

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.