ArticleAmerican journal of respiratory and critical care medicine2020
A Network of Sputum MicroRNAs Is Associated with Neutrophilic Airway Inflammation in Asthma.
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In one paragraph
Article in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.
- Meta-analysis of microarray data to identify potential signature genes and MiRNAs associated with the pathogenesis of asthma.Journal of translational medicine · 2025Pooled it
- AI-based prediction of aspirin-exacerbated respiratory disease using nasal epithelial mRNA expression profiles.The journal of allergy and clinical immunology. Global · 2026Article
- MicroRNA-mediated regulation of inflammatory gene expression in asthma.Inflammopharmacology · 2026Review
- Integrated molecular networks reveal latent components distinguishing type 2-high and type 2-low asthma.BMJ open respiratory research · 2026Article
- Differences in microRNA levels across metabo-endotypes reveal novel insights into asthma heterogeneity.Respiratory research · 2026Article
- Acupuncture Treatment Alleviating Pyroptosis on Asthma Inflammation in Mice via Micro-RNA-223/NLRP3 Pathway.Mediators of inflammation · 2026Article
- New mechanisms in diisocyanate-mediated allergy/toxicity: are microRNAs in play?Current opinion in allergy and clinical immunology · 2025Review
- Development of an asthma health-care burden score as a measure of severity and predictor of remission in SARP III and U-BIOPRED: results from two major longitudinal asthma cohorts.The Lancet. Respiratory medicine · 2025Article
- microRNA-2117 Negatively Regulates Liver Cancer Stem Cells Expansion and Chemoresistance Via Targeting SOX2.Molecular carcinogenesis · 2025Article
- Specific microRNA Profile Associated with Inflammation and Lipid Metabolism for Stratifying Allergic Asthma Severity.International journal of molecular sciences · 2024Article
- Review
- Advances in non-type 2 severe asthma: from molecular insights to novel treatment strategies.The European respiratory journal · 2024Review
- Integrated DNA methylation analysis reveals a potential role for PTPRN2 in Marfan syndrome scoliosis.JOR spine · 2024Article
- Upregulated microRNA-125b-5p in patients with asthma-COPD overlap mediates oxidative stress and late apoptosis via targeting IL6R/TRIAP1 signaling.Respiratory research · 2024Article
- Gastric tubular adenocarcinoma with diffuse neutrophils infiltrating: characteristics and probable treatment strategy.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2024Article
- Data Mining of Microarray Datasets in Translational Neuroscience.Brain sciences · 2023Review
- Air Pollution and Diet: Potential Interacting Exposures in Asthma.Current allergy and asthma reports · 2023Review
- Nasal airway microRNA profiling of infants with severe bronchiolitis and risk of childhood asthma: a multicentre prospective study.The European respiratory journal · 2023Article
- Phenotype overlap in the natural history of asthma.European respiratory review : an official journal of the European Respiratory Society · 2023Review
- Air Pollution and microRNAs: The Role of Association in Airway Inflammation.Life (Basel, Switzerland) · 2023Review
Corrections and comments
- Commented on by
Authors and funding
17 authors at 2 institutions in 1 country.
Jose L GomezPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.ORCID 0000-0002-6521-6318
Ailu ChenPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Maria Paula DiazPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Nicholas ZirnPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Amolika GuptaPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Clemente BrittoPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Maor SaulerPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Xiting YanPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Emma StewartPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Kyle SanterianPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Nicole GrantPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Qing LiuPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Rebecca FryDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina; and.
Julia RagerDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina; and.
Lauren CohnPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Neil AlexisDepartment of Pediatrics, University of North Carolina, Chapel Hill, North Carolina.
Geoffrey L ChuppPulmonary, Critical Care and Sleep Medicine, Internal Medicine, Yale School of Medicine, New Haven, Connecticut.
Yale University · USUniversity of North Carolina at Chapel Hill · US
Funding
Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MBiostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3MP2X7 and the Inflammasome Pathways in Lung InflammationU19AI077437 · NIAID · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2008 to 2013
$9.2MTranslational Research Center for CAM Therapy of AsthmaP01AT002620 · NCCIH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2004 to 2008
$5.9MLongitudinal Analysis of Transcriptomic Endophenotypes in AsthmaR01HL118346 · NHLBI · YALE UNIVERSITY · PI CHUPP, GEOFFREY L · 2013 to 2016
$3.3MIn utero exposure to arsenic, links to epigenetic alterations and diseaseR01ES019315 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FRY, REBECCA · 2010 to 2014
$2.3MInvestigating gene x environment interaction using human exposures to O3 & LPSRC1ES018417 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI PEDEN, DAVID B. · 2009 to 2010
$977kFunctional role of hsa-miR-504 in airway inflammation and remodeling in asthmaK01HL125474 · NHLBI · YALE UNIVERSITY · PI GOMEZ-VILLALOBOS, JOSE LUIS · 2015 to 2019
$835kDeep and Integrative Analysis of RNA Sequencing Data to Identify Pathogenesis Heterogeneity of Chronic Lung DiseaseR21LM012884 · NLM · YALE UNIVERSITY · PI YAN, XITING · 2018 to 2019
$415kNCATS NIH HHS UL1 TR001863NCCIH NIH HHS P01 AT002620NHLBI NIH HHS K01 HL125474NHLBI NIH HHS R01 HL118346NIAID NIH HHS U19 AI077437NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES019315NIEHS NIH HHS RC1 ES018417NIEHS NIH HHS T32 ES007018NLM NIH HHS R21 LM012884
Abstract
PubMed holds no abstract for this paper.
Indexed as
Gene Regulatory NetworksSeverity of Illness IndexAdultAgedAsthmaBiomarkersCase-Control StudiesCross-Sectional StudiesFemaleGenome-Wide Association StudyHealthy VolunteersHumansMaleMicroRNAsMiddle AgedNeutrophilsBiomarkersMicroRNAsRNA, Messengergene networkshsa-miR-223-3pmicroRNAssevere asthmaTH17
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.