Evidence map›Paper›PMID 32255605›Full record

ArticleACS chemical biology2020

A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography.

Yangjie Huang, Ning Zhao, Yung-Hua Wang, Charles Truillet, Junnian Wei, Joseph E Blecha, Henry F VanBrocklin, Youngho Seo, Mohd Sayeed, Brian J Feldman and 7 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. The Synthesis and Structural Requirements for Measuring Glucocorticoid Receptor Expression In Vivo with (±)-Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 2 countries.

Yangjie HuangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Ning ZhaoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.ORCID 0000-0003-3699-3369
Yung-Hua WangDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Charles TruilletImagerie Moleculaire in Vivo, INSERM, CEA, Université Paris Sud, CNRS, Universite Paris Saclay, CEA-Service Hospitalier Frederic Joliot, Orsay 94100, France.
Junnian WeiDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Joseph E BlechaDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Henry F VanBrocklinDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Youngho SeoDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Mohd SayeedDepartment of Pediatrics, University of California San Francisco, San Francisco, California 94158, United States.
Brian J FeldmanDepartment of Pediatrics, University of California San Francisco, San Francisco, California 94158, United States.
Rahul AggarwalHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94158, United States.
Spencer C BehrDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Hao ShaoDepartment of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, California 94158, United States.
David M WilsonDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.ORCID 0000-0002-1095-046X
Javier E Villanueva-MeyerDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.
Jason E GestwickiHelen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, California 94158, United States.ORCID 0000-0002-6125-3154
Michael J EvansDepartment of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94158, United States.ORCID 0000-0003-4947-1316
University of California, San Francisco · USUniversité Paris-Sud · FR

Funding

Molecular Chaperones and Small MoleculesR01NS059690 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jason E Gestwicki · 2008 to 2026
$7.9M
Integrated Systemic and Adipose Depot-Specific Regulation of AdipogenesisR01DK114217 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FELDMAN, BRIAN J · 2017 to 2021
$2.1M
Development and translation of a novel radioligand to measure pathological changes in glucocorticoid receptor expression in the brainR01MH115043 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EVANS, MICHAEL JOHN · 2018 to 2020
$2.0M
NIDDK NIH HHS R01 DK114217NIMH NIH HHS R01 MH115043NINDS NIH HHS R01 NS059690
6 · The paper itself

Abstract

The complexity of glucocorticoid receptor (GR) signaling cannot be measured with direct tissue analysis in living subjects, which has stifled our understanding of GR's role in human physiology or disease and impeded the development of selective GR modulators. Herein, we report

Indexed as

AnimalsDexamethasoneFluorine RadioisotopesGene ExpressionGlucocorticoidsMaleMiceMice, Inbred C57BLMice, KnockoutPositron-Emission TomographyQuinolinesReceptors, GlucocorticoidDexamethasoneFluorine-18Fluorine RadioisotopesGlucocorticoidsQuinolinesReceptors, Glucocorticoid

Identifiers

PMID32255605
PMCPMC8031368
OpenAlexW3015073046

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.