ReviewAngewandte Chemie (International ed. in English)2020
The Huisgen Reaction: Milestones of the 1,3-Dipolar Cycloaddition.
Review in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers.
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Who cites it
124 citing papers in PubMed.
- Triazole-Linked Pyrimidine Nucleoside Dimers: Design, Synthesis, and Applications in Medicinal and Nucleic Acid Chemistry. Part IV.Chemical biology & drug design · 2026Article
- Diradical Character of Cyclic Allenes Enables Their Thermal (2 + 2) Cycloadditions.Journal of the American Chemical Society · 2026Article
- Novel Triazole-Linked Xanthine-Steroid Hybrids: Molecular Docking and In Vitro Evaluation Against α-Glucosidase and MCF-7 Cells.Chemistry & biodiversity · 2026Article
- Beyond traditional strain-promoted azide-alkyne cycloadditions by achieving orthogonality and rapid kinetics with fluoroalkyl azides.Communications chemistry · 2026Article
- Versatility of Click Chemistry in Hydrogel Synthesis: From Molecular Strategies to Applications in Regenerative Medicine.Gels (Basel, Switzerland) · 2026Review
- Topological classification of cycloadditions occurring on-surface and in the solid-state.Communications chemistry · 2025Article
- Synthesis of xanthenone fused spiro pyrrolidine oxindoles via multicomponent [3 + 2] cycloaddition reactions.Molecular diversity · 2025Article
- Surface modification of probiotics at single-cell resolution: Strategies, applications, and future directions in inflammatory bowel disease.Materials today. Bio · 2025Review
- Green and Sustainable Chemistry Approaches on Azide-Based Click Reactions in Polymer Science.Macromolecular rapid communications · 2025Review
- Asymmetric formal [1 + 2 + 2]-cycloaddition of diazoamides with enamines and carbonyl compounds.Nature communications · 2025Article
- Computational Study of Ignored Pericyclic Reactions: Rearrangements of 1,2-Bis(Diazo)Alkanes to 1,2,3,4-Tetrazines and Subsequent Fragmentations.Angewandte Chemie (International ed. in English) · 2025Article
- Electrochemical Dehydration Reaction.ChemSusChem · 2025Review
- A Remarkable Selectivity Observed in Hetero-Diels-Alder Reactions of Levoglucosenone (LGO) with Thiochalcones: An Experimental and Computational Study.Molecules (Basel, Switzerland) · 2025Article
- Alkynyl-Gold Carbazole Hybrids: Luminescence and Functionalization via iClick Reactions.Inorganic chemistry · 2025Article
- Advancements in the design and development of pyrazoline-based antimycobacterial agents: an update and future perspectives.RSC advances · 2025Review
- Exploring Metal-Free Click Reactions: New Frontiers in Glycochemistry and Bioconjugation.Bioconjugate chemistry · 2025Review
- The Genuine Carbene Conundrum.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Titanocenes functionalization with high chemical diversity via titanium protecting groups.Communications chemistry · 2025Article
- Reactivity of Pnictaalumenes Towards 1,3-Dipole Molecules.Angewandte Chemie (International ed. in English) · 2025Article
- Metal-Free APolymers · 2025Article
64 more citing papers are in PubMed but not listed here.
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2 authors.
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Abstract
The concept of 1,3-dipolar cycloadditions was presented by Rolf Huisgen 60 years ago. Previously unknown reactive intermediates, for example azomethine ylides, were introduced to organic chemistry and the (3+2) cycloadditions of 1,3-dipoles to multiple-bond systems (Huisgen reaction) developed into one of the most versatile synthetic methods in heterocyclic chemistry. In this Review, we present the history of this research area, highlight important older reports, and describe the evolution and further development of the concept. The most important mechanistic and synthetic results are discussed. Quantum-mechanical calculations support the concerted mechanism always favored by R. Huisgen; however, in extreme cases intermediates may be involved. The impact of 1,3-dipolar cycloadditions on the click chemistry concept of K. B. Sharpless will also be discussed.
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