ArticleJournal of the American Geriatrics Society2020
Does Alzheimer's Disease and Related Dementias Modify Delirium Severity and Hospital Outcomes?
Article in Journal of the American Geriatrics Society, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Pooled it
- Who Is Delirium Worse For?Journal of the American Geriatrics Society · 2026Article
- Delirium and incident nursing home admission among people with and without dementia.Age and ageing · 2026Article
- Frequent in dementia, deadliest without it: delirium and mortality in hospitalised older adults.Age and ageing · 2026Article
- Using novel natural language processing approaches to examine age-friendly communication about nursing Nome residents with dementia.The Gerontologist · 2026Article
- Pulling Back the Curtain on Hospital Dementia Detection: Validation of the Informant-Based Clinical Dementia Rating.Journal of the American Geriatrics Society · 2025Article
- Untangling the complex web of avoidable nursing home-to-hospital transfers of residents with dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Assessing Delirium Severity in Dementia: Item Development and Psychometric Validation for a Delirium Severity Instrument.Journal of gerontological nursing · 2024Article
- Outcomes and cost analysis of patients with dementia in the intensive care unit: a population-based cohort study.BMC health services research · 2023Article
- Extremes of baseline cognitive function determine the severity of delirium: a population study.Brain : a journal of neurology · 2023Article
- One-year Medicare costs associated with delirium in older hospitalized patients with and without Alzheimer's disease dementia and related disorders.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Delirium Mediates Incidence of Hospital-Associated Disability Among Older Adults.Journal of the American Medical Directors Association · 2023Article
- Characteristics of elderspeak communication in hospital dementia care: Findings from The Nurse Talk observational study.International journal of nursing studies · 2022Observational
- Elderspeak communication and pain severity as modifiable factors to rejection of care in hospital dementia care.Journal of the American Geriatrics Society · 2022Article
- Effect of Alzheimer Disease on Prognosis of Intensive Care Unit (ICU) Patients: A Propensity Score Matching Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2022Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesWe examined the association between delirium severity and outcomes of delirium among persons with and without Alzheimer's disease and related dementias (ADRD).
designProspective cohort study.
settingAcademic tertiary medical center.
participantsA total of 352 medical and surgical patients. MEASUREMENTS: Delirium incidence and severity were rated daily using the Confusion Assessment Method (CAM) and CAM-Severity (CAM-S) score during hospitalization. Severe delirium was defined as a CAM-S Short Form score in the highest tertile (3-7 points out of 7). ADRD status was determined by a clinical consensus process. Clinical outcomes included prolonged length of stay (>6 d), discharge to post-acute nursing facility, any decline in activities of daily living (ADLs) at 1 month from prehospital baseline, ongoing nursing facility stay, and mortality.
resultsPatients with ADRD (n = 85 [24%]) had a significantly higher relative risk (RR) for incident delirium (RR = 2.31; 95% confidence interval [CI] = 1.64-3.28) and higher peak CAM-S scores (mean difference = 1.24 points; CI = .83-1.65; P < .001). Among patients with ADRD, severe delirium significantly increased the RR for nursing facility stay (RR = 2.22; CI = 1.05-4.69; P = .04) and increased the RR for mortality (RR = 2.10; CI = .89-4.98; P = .09). Among patients without ADRD, severe delirium was associated with a significantly increased risk for all poor outcomes except mortality including prolonged length of stay in the hospital (RR = 1.47; CI = 1.18-1.82) and discharge to a post-acute nursing facility (RR = 2.17; CI = 1.58-2.98) plus decline in ADLs (RR = 1.30; CI = 1.05-1.60) and nursing facility stay at 1 month (RR = 1.93; CI = 1.31-2.83).
conclusionSevere delirium is associated with increased risk for poor clinical outcomes in patients with and without ADRD. In both groups, severe delirium increased risk of nursing home placement. In patients with ADRD, delirium was more severe and associated with a trend toward increased mortality at 1 month. Although the increased risk remains substantial by RR, the study had limited power to examine the rarer outcome of death. J Am Geriatr Soc 68:1722-1730, 2020.
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