ArticleeLife2020
Endogenous itaconate is not required for particulate matter-induced NRF2 expression or inflammatory response.
Open access · goldAbstract read
In one paragraph
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 59 citations in OpenAlex.
- Lipocalin-2 Restores Mitochondrial and Antioxidant Adaptation in a Strain-Specific Manner During LPS Induced Sepsis.Journal of cellular physiology · 2026Article
- Role of the ionized-to-total calcium ratio in predicting sepsis mortality: a retrospective analysis from the MIMIC-IV database.BMC infectious diseases · 2026Article
- Crosstalk of mitochondrial dysfunction and macrophage polarization in sepsis.Frontiers in immunology · 2026Review
- Metabolic control of neuroinflammation: focus on itaconate and its derivatives in CNS disorders.Frontiers in immunology · 2026Review
- Itaconate Modulates Neutrophil Homeostasis to Ameliorate Airway Inflammation in Diesel Exhaust Particles-exacerbated Asthma via Inhibiting NETs Formation.International journal of biological sciences · 2026Article
- 4-Octyl Itaconate Attenuates Postmenopausal Osteoporosis by Inhibiting Ferroptosis and Enhancing Osteogenesis via the Nrf2 Pathway.Inflammation · 2025Article
- Reprogramming immunity with itaconate: metabolic mechanisms and therapeutic perspectives.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Review
- HIF-1 regulates mitochondrial function in bone marrow-derived macrophages but not in tissue-resident alveolar macrophages.Scientific reports · 2025Article
- 4-Octyl Itaconate Alleviates Myocardial Ischemia-Reperfusion Injury Through Promoting Angiogenesis via ERK Signaling Activation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- 4-Octyl Itaconate ameliorates diesel exhaust particle-induced oxidative stress in nasal epithelial cells.Frontiers in immunology · 2025Article
- The role and therapeutic potential of itaconate in lung disease.Cellular & molecular biology letters · 2024Review
- Metabolic Messengers: itaconate.Nature metabolism · 2024Review
- ACOD1, rather than itaconate, facilitates p62-mediated activation of Nrf2 in microglia post spinal cord contusion.Clinical and translational medicine · 2024Article
- Oral streptococciInfection and immunity · 2024Article
- Itaconate as a key regulator of respiratory disease.Clinical and experimental immunology · 2024Review
- Dynamin-related protein 1 is a critical regulator of mitochondrial calcium homeostasis during myocardial ischemia/reperfusion injury.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- Aconitate decarboxylase 1 mediates the acute airway inflammatory response to environmental exposures.Frontiers in immunology · 2024Article
- Keap1-Nrf2 pathway: a key mechanism in the occurrence and development of cancer.Frontiers in oncology · 2024Review
- Itaconate suppresses atherosclerosis by activating a Nrf2-dependent antiinflammatory response in macrophages in mice.The Journal of clinical investigation · 2023Article
- Nrf2 in TIME: The Emerging Role of Nuclear Factor Erythroid 2-Related Factor 2 in the Tumor Immune Microenvironment.Molecules and cells · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Kaitlyn A SunDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, United States.
Yan LiCenter for Research Bioinformatics, The University of Chicago, Chicago, United States.
Angelo Y MelitonDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, United States.
Parker S WoodsDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, United States.
Lucas M KimmigDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, United States.
Rengül Cetin-AtalayDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, United States.
Robert B HamanakaDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, United States.ORCID 0000-0002-8909-356X
Gökhan M MutluDepartment of Medicine, Section of Pulmonary and Critical Care Medicine, The University of Chicago, Chicago, United States.ORCID 0000-0002-2056-612X
University of Chicago · US
Funding
RESEARCH TRAINING IN RESPIRATORY BIOLOGYT32HL007605 · NHLBI · UNIVERSITY OF CHICAGO · PI Yun Fang, Gokhan M. Mutlu · 1985 to 2026
$18.1MPilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6MMechanisms Underlying Sympathetic Activation-dependent Endothelial Cell Activation by Chronic Intermittent HypoxiaP01HL144454 · NHLBI · UNIVERSITY OF CHICAGO · PI PRABHAKAR, NANDURI R · 2019 to 2023
$12.7MRole of alveolar macrophages in particulate matter-induced cardiopulmonary diseaseR01ES015024 · NIEHS · UNIVERSITY OF CHICAGO · PI MUTLU, GOKHAN M. · 2006 to 2022
$6.1MParticulate matter-induced changes in DNA methylome and transcriptomeU01ES026718 · NIEHS · UNIVERSITY OF CHICAGO · PI MUTLU, GOKHAN M. · 2016 to 2019
$2.5MMetabolic Regulation of Epidermal HomeostasisK01AR066579 · NIAMS · UNIVERSITY OF CHICAGO · PI HAMANAKA, ROBERT BRIAN · 2014 to 2018
$424kNHLBI NIH HHS P01 HL144454NHLBI NIH HHS T32 HL007605NIAMS NIH HHS K01 AR066579NIEHS NIH HHS P30 ES027792NIEHS NIH HHS R01ES010524NIEHS NIH HHS R01 ES015024NIEHS NIH HHS R01ES015024NIEHS NIH HHS U01 ES026718Respiratory Health Association RHA2018-01-IPFU.S. Department of Defense W81XWH-16-1-0711
Abstract
Particulate matter (PM) air pollution causes cardiopulmonary mortality via macrophage-driven lung inflammation; however, the mechanisms are incompletely understood. RNA-sequencing demonstrated
Indexed as
InflammationAnimalsCarboxy-LyasesMacrophages, AlveolarMiceMice, KnockoutNF-E2-Related Factor 2OxygenParticulate MatterRNA-SeqSignal TransductionSuccinatesaconitate decarboxylaseCarboxy-Lyasesitaconic acidNfe2l2 protein, mouseNF-E2-Related Factor 2OxygenParticulate MatterSuccinatescell biologyimmunologyinflammationitaconatemetabolismmitochondriamouse
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.