ArticleThe Journal of comparative neurology2020
Mapping mesoscale cortical connectivity in monkey sensorimotor cortex with optical imaging and microstimulation.
Article in The Journal of comparative neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
- Prioritized nonlinear modeling of shared dynamics across neural populations.Journal of neural engineering · 2026Article
- Mid-Infrared Light Exhibits Tissue-Specific Transmittance and Modulates Neural Signal Conduction Along Axons.Neuroscience bulletin · 2026Article
- Characterizing Evoked Movement Patterns and Connectivity in Sensorimotor Cortex After Sensory Loss in Squirrel Monkeys.The Journal of comparative neurology · 2025Article
- Separable global and local beta burst dynamics in motor cortex of primates.bioRxiv : the preprint server for biology · 2025Article
- Brainwide mesoscale functional networks revealed by focal infrared neural stimulation of the amygdala.National science review · 2025Article
- A novel interface for cortical columnar neuromodulation with multipoint infrared neural stimulation.Nature communications · 2024Article
- Article
- Functional imaging and anatomical connections in squirrel monkeys reveal parietal-frontal circuits underlying eye movements.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Stimulation-Evoked Effective Connectivity (SEEC): An in-vivo approach for defining mesoscale corticocortical connectivity.Journal of neuroscience methods · 2023Article
- Cortical connectivity is embedded in resting state at columnar resolution.Progress in neurobiology · 2022Article
- Modular Organization of Signal Transmission in Primate Somatosensory Cortex.Frontiers in neuroanatomy · 2022Article
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- Principles of Intrinsic Motor Cortex Connectivity in Primates.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
To map in vivo cortical circuitry at the mesoscale, we applied a novel approach to map interareal functional connectivity. Electrical intracortical microstimulation (ICMS) in conjunction with optical imaging of intrinsic signals (OIS) was used map functional connections in somatosensory cortical areas in anesthetized squirrel monkeys. ICMS produced activations that were focal and that displayed responses which were stimulation intensity dependent. ICMS in supragranular layers of Brodmann Areas 3b, 1, 2, 3a, and M1 evoked interareal activation patterns that were topographically appropriate and appeared consistent with known anatomical connectivity. Specifically, ICMS revealed Area 3b connections with Area 1; Area 1 connections with Areas 2 and 3a; Area 2 connections with Areas 1, 3a, and M1; Area 3a connections with Areas M1, 1, and 2; and M1 connections with Areas 3a, 1, and 2. These somatosensory connectivity patterns were reminiscent of feedforward patterns observed anatomically, although feedback contributions are also likely present. Further consistent with anatomical connectivity, intra-areal and intra-areal patterns of activation were patchy with patch sizes of 200-300 μm. In summary, ICMS with OIS is a novel approach for mapping interareal and intra-areal connections in vivo. Comparisons with feedforward and feedback anatomical connectivity are discussed.
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Registered trials
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