Evidence map›Paper›PMID 32255136›Full record

ArticleLab on a chip2020

Hybrid paper and 3D-printed microfluidic device for electrochemical detection of Ag nanoparticle labels.

Charuksha Walgama, Michael P Nguyen, Lisa M Boatner, Ian Richards, Richard M Crooks

Abstract read
In one paragraph

Article in Lab on a chip, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Nanomaterials-based sensors for the detection of COVID-19: A review.Bioengineering & translational medicine · 2022
    Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Fabrication and Applications of Microfluidic Devices: A Review.International journal of molecular sciences · 2021
    Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Charuksha WalgamaDepartment of Chemistry and Texas Materials Institute, The University of Texas at Austin, 100 East 24th Street, Stop A1590, Austin, Texas 78712-1224, USA. crooks@cm.utexas.edu.ORCID 0000-0002-5549-0436
Michael P NguyenDepartment of Chemistry and Texas Materials Institute, The University of Texas at Austin, 100 East 24th Street, Stop A1590, Austin, Texas 78712-1224, USA. crooks@cm.utexas.edu.
Lisa M BoatnerDepartment of Chemistry and Texas Materials Institute, The University of Texas at Austin, 100 East 24th Street, Stop A1590, Austin, Texas 78712-1224, USA. crooks@cm.utexas.edu.ORCID 0000-0003-0757-4982
Ian RichardsInteractives Executive Excellence LLC, Austin, Texas 78733, USA.
Richard M CrooksDepartment of Chemistry and Texas Materials Institute, The University of Texas at Austin, 100 East 24th Street, Stop A1590, Austin, Texas 78712-1224, USA. crooks@cm.utexas.edu.ORCID 0000-0001-5186-4878

Funding

A disposable NT-proBNP sensor for managing heart failure at homeR01HL137601 · NHLBI · UNIVERSITY OF TEXAS AT AUSTIN · PI CROOKS, RICHARD M · 2017 to 2020
$2.0M
NHLBI NIH HHS R01 HL137601
6 · The paper itself

Abstract

In the present article we report a new hybrid microfluidic device (hyFlow) comprising a disposable paper electrode and a three-dimensional (3D) printed plastic chip for the electrochemical detection of a magnetic bead-silver nanoparticle (MB-AgNP) bioconjugate. This hybrid device evolved due to the difficulty of incorporating micron-scale MBs into paper-only fluidic devices. Specifically, paper fluidic devices can entrap MB-containing conjugates within their cellulose or nitrocellulose fiber matrix. The hyFlow system was designed to minimize such issues and transport MB conjugates more efficiently to the electrochemical detection zone of the device. The hyFlow system retains the benefit of fluid transport by pressure-driven flow, however, no pump is required for its operation. The hyFlow device is capable of detecting either pre-formed MB-AgNP conjugates or conjugates formed in situ. The detection limit of AgNPs using this device is 12 pM, which represents just 22 AgNPs per MB.

Indexed as

Electrochemical TechniquesLab-On-A-Chip DevicesPaperPrinting, Three-DimensionalMetal NanoparticlesSilverSilver

Identifiers

PMID32255136
PMCPMC7204514

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.