ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2020
The early life microbiota protects neonatal mice from pathological small intestinal epithelial cell shedding.
Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Maternal probiotic exposure enhances CD8 T cell protective neonatal immunity and modulates offspring metabolome to control influenza virus infection.Gut microbes · 2025Article
- Neonatal infection withInfection and immunity · 2025Article
- Article
- Microbiota assembly of specific pathogen-free neonatal mice.bioRxiv : the preprint server for biology · 2025Article
- Early-life gut microbiota assembly patterns are conserved between laboratory and wild mice.Communications biology · 2024Article
- Metabolic immaturity and breastmilk bile acid metabolites are central determinants of heightened newborn vulnerability to norovirus diarrhea.Cell host & microbe · 2024Article
- MAIT cells monitor intestinal dysbiosis and contribute to host protection during colitis.Science immunology · 2024Article
- Intergenerational protective anti-gut commensal immunoglobulin G originates in early life.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Non-professional efferocytosis of Salmonella-infected intestinal epithelial cells in the neonatal host.The Journal of experimental medicine · 2024Article
- What we need to know about the germ-free animal models.AIMS microbiology · 2024Review
- The contribution of maternal oral, vaginal, and gut microbiota to the developing offspring gut.Scientific reports · 2023Article
- Postnatal intestinal mucosa and gut microbial composition develop hand in hand: A mouse study.Biomedical journal · 2023Article
- Host Age Prediction from Fecal Microbiota Composition in Male C57BL/6J Mice.Microbiology spectrum · 2022Article
- Maternal gut microbiota Bifidobacterium promotes placental morphogenesis, nutrient transport and fetal growth in mice.Cellular and molecular life sciences : CMLS · 2022Article
- Impact of Epithelial Cell Shedding on Intestinal Homeostasis.International journal of molecular sciences · 2022Review
- In vitro interaction network of a synthetic gut bacterial community.The ISME journal · 2022Article
- Gut Microbial Metabolite-Mediated Regulation of the Intestinal Barrier in the Pathogenesis of Inflammatory Bowel Disease.Nutrients · 2021Review
- Synergistic Protective Effect of Konjac Mannan Oligosaccharides andFrontiers in immunology · 2021Article
- Enzyme-Treated Soybean Meal Replacing Extruded Full-Fat Soybean Affects Nitrogen Digestibility, Cecal Fermentation Characteristics and Bacterial Community of Newly Weaned Piglets.Frontiers in veterinary science · 2021Article
- Maternal Microbiota, Early Life Colonization and Breast Milk Drive Immune Development in the Newborn.Frontiers in immunology · 2021Review
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Authors and funding
10 authors.
Funding
Abstract
The early life gut microbiota plays a crucial role in regulating and maintaining the intestinal barrier, with disturbances in these communities linked to dysregulated renewal and replenishment of intestinal epithelial cells. Here we sought to determine pathological cell shedding outcomes throughout the postnatal developmental period, and which host and microbial factors mediate these responses. Surprisingly, neonatal mice (Day 14 and 21) were highly refractory to induction of cell shedding after intraperitoneal administration of liposaccharide (LPS), with Day 29 mice showing strong pathological responses, more similar to those observed in adult mice. These differential responses were not linked to defects in the cellular mechanisms and pathways known to regulate cell shedding responses. When we profiled microbiota and metabolites, we observed significant alterations. Neonatal mice had high relative abundances of Streptococcus, Escherichia, and Enterococcus and increased primary bile acids. In contrast, older mice were dominated by Candidatus Arthromitus, Alistipes, and Lachnoclostridium, and had increased concentrations of SCFAs and methyamines. Antibiotic treatment of neonates restored LPS-induced small intestinal cell shedding, whereas adult fecal microbiota transplant alone had no effect. Our findings further support the importance of the early life window for microbiota-epithelial interactions in the presence of inflammatory stimuli and highlights areas for further investigation.
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