Evidence map›Paper›PMID 32253741›Full record

ArticleCell stress & chaperones2020

The effect of hyperbaric oxygen on mitochondrial and glycolytic energy metabolism: the caloristasis concept.

Didem Tezgin, Charles Giardina, George A Perdrizet, Lawrence E Hightower

Open access · bronzeAbstract read
In one paragraph

Article in Cell stress & chaperones, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.1field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Hyperbaric Oxygen Therapy in Experimental Autoimmune Myocarditis: Insights from Preclinical Models to Translational Perspectives.Pathophysiology : the official journal of the International Society for Pathophysiology · 2026
    Review
  3. Article
  4. Review
  5. Article
  6. Hyperbaric Oxygen Therapy for the Treatment of Bone-Related Diseases.International journal of molecular sciences · 2025
    Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Hyperoxia: Effective Mechanism of Hyperbaric Treatment at Mild-Pressure.International journal of molecular sciences · 2024
    Review
  13. Observational
  14. Review
  15. Article
  16. Review
  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Didem TezginDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, 06269-3125, USA.
Charles GiardinaDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, 06269-3125, USA.
George A PerdrizetDepartment of Surgery, Wound Care and Hyperbaric Medicine, Hartford Health Care and the Hospital of Central Connecticut, New Britain, CT, 06050, USA.
Lawrence E HightowerDepartment of Molecular and Cell Biology, University of Connecticut, Storrs, CT, 06269-3125, USA. lawrence.hightower@uconn.edu.
University of Connecticut · USThe Hospital of Central Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We present new data on the effects of HBOT on human kidney (HK-2) cell metabolism using a SeaHorse XF Analyzer to evaluate separately the state of mitochondrial and glycolytic energy metabolism. The data are discussed in the context of the concept of cellular caloristasis networks. The information on the changes in cellular energy metabolism stimulated by HBOT presented here provides new insights into the cellular energy state and mitochondrial environment in which sHSPs function. These data will be useful in forming testable hypotheses about the functions of translocated sHSPs in human mitochondria responding to stressors.

Indexed as

Energy MetabolismGlycolysisHyperbaric OxygenationCell LineHumansMitochondriaOxidative StressOxygenOxygenCaloristasisCytoprotectionDiabetic kidney diseaseHBOTHyperbaric oxygen therapyMitochondriaOxidative stressProteostasisSmall HSPs

Identifiers

PMID32253741
PMCPMC7332662
OpenAlexW3014887856

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.