ArticleJournal of endocrinological investigation2020
Morphological and microstructural brain changes in thyroid-associated ophthalmopathy: a combined voxel-based morphometry and diffusion tensor imaging study.
Article in Journal of endocrinological investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Right-lateralized maladaptive topological reorganization in hyperthyroidism.Journal of neuroendocrinology · 2026Article
- Thyroid-stimulating hormone receptor mediates peripheral-central neuroimmune crosstalk in autoimmune thyroid diseases.BMC medicine · 2026Article
- Resting-State Brain Activity, Functional Connectivity, and Orbital Imaging Changes in Restrictive Myopathy Associated with Thyroid Eye Disease.Eye and brain · 2026Article
- Glymphatic System Dysfunction in Thyroid Eye Disease Associated with Disease Activity and Duration.Journal of inflammation research · 2025Article
- Diagnosis of dysthyroid optic neuropathy: combined value of orbital MRI and intracranial visual pathway diffusion kurtosis imaging.European radiology · 2024Article
- Immune-related visual dysfunction in thyroid eye disease: a combined orbital and brain neuroimaging study.European radiology · 2024Article
- Mapping Thyroid Hormone Action in the Human Brain.Thyroid : official journal of the American Thyroid Association · 2024Review
- Functional decoding and meta-analytic connectivity modeling in thyroid-associated ophthalmopathy.Heliyon · 2024Article
- Diffusion and functional MRI reveal microstructural and network connectivity impairment in adult-onset neuronal intranuclear inclusion disease.Frontiers in aging neuroscience · 2024Article
- Specific static and dynamic functional network connectivity changes in thyroid-associated ophthalmopathy and it predictive values using machine learning.Frontiers in neuroscience · 2024Article
- Development and Validation of a Prediction Model for Co-Occurring Moderate-to-Severe Anxiety Symptoms in First-Episode and Drug Naïve Patients With Major Depressive Disorder.Depression and anxiety · 2024Article
- Altered dynamic brain activity and functional connectivity in thyroid-associated ophthalmopathy.Human brain mapping · 2023Article
- Graves' Eye Disease: Clinical and Radiological Diagnosis.Biomedicines · 2023Review
- Reduced cortical complexity in patients with thyroid-associated ophthalmopathy.Brain imaging and behavior · 2022Article
- Local-to-Remote Brain Functional Connectivity in Patients with Thyroid-Associated Ophthalmopathy and Assessment of Its Predictive Value Using Machine Learning.International journal of general medicine · 2022Article
- Altered Long- and Short-Range Functional Connectivity Density in Patients With Thyroid-Associated Ophthalmopathy: A Resting-State fMRI Study.Frontiers in neurology · 2022Article
- Reduction of Interhemispheric Homotopic Connectivity in Cognitive and Visual Information Processing Pathways in Patients With Thyroid-Associated Ophthalmopathy.Frontiers in human neuroscience · 2022Article
- Thyroid-associated ophthalmopathy: Using diffusion tensor imaging to evaluate visual pathway microstructural changes.Frontiers in neurology · 2022Article
- Neurobiological substrates of major psychiatry disorders: transdiagnostic associations between white matter abnormalities, neuregulin 1 and clinical manifestation.Journal of psychiatry & neuroscience : JPN · 2021Article
- Disrupted Topological Organization of the Brain Structural Network in Patients With Thyroid-Associated Ophthalmopathy.Investigative ophthalmology & visual science · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeTo explore the morphological and microstructural changes of grey and white matter in the patients of thyroid-associated ophthalmopathy (TAO).
methodsTwenty-five TAO patients and 25 well-matched healthy controls were recruited. Structural T1- and diffusion-weighted magnetic resonance imaging data were analyzed using voxel-based morphometry and voxel-based analysis of diffusion tensor imaging.
resultsCompared with healthy controls, TAO group showed significantly decreased grey matter volume in the brain region of the right middle frontal gyrus. Meanwhile, TAO group showed significantly decreased fractional anisotropy (FA), but increased mean, axial and radial diffusivities in the brain regions of the right superior occipital gyrus, middle occipital gyrus and cuneus in TAO group. In addition, the FA value in significant brain regions showed a positive correlation with visual acuity (r = 0.456, P = 0.025) and a negative correlation with disease duration (r = - 0.609, P = 0.003).
conclusionSignificant morphological and microstructural abnormalities in areas corresponding to known functional deficits of vision and cognition could be found in TAO patients. These results extended our understanding of neural relationships with TAO.
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