Evidence map›Paper›PMID 32253545›Full record

ArticleChild psychiatry and human development2021

Antidepressant Use in a 3- to 12-Year Follow-up of Anxious Youth: Results from the CAMELS Trial.

Elana R Kagan, Hannah E Frank, Lesley A Norris, Sophie A Palitz, Erika A Chiappini, Mark J Knepley, Margaret E Crane, Katherine E Phillips, Golda S Ginsburg, Courtney Keeton and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Child psychiatry and human development, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 1 country.

Elana R KaganDepartment of Behavioral Psychology, Kennedy Krieger Institute/Johns Hopkins School of Medicine, 720 Aliceanna Street, Baltimore, MD, 210202, USA. elana.kagan@gmail.com.
Hannah E FrankDepartment of Psychology, Temple University, Philadelphia, PA, USA.
Lesley A NorrisDepartment of Psychology, Temple University, Philadelphia, PA, USA.
Sophie A PalitzDepartment of Psychology, Temple University, Philadelphia, PA, USA.
Erika A ChiappiniDivision of Child & Adolescent Psychiatry, Johns Hopkins, Baltimore, MD, USA.
Mark J KnepleyDepartment of Psychology, Temple University, Philadelphia, PA, USA.
Margaret E CraneDepartment of Psychology, Temple University, Philadelphia, PA, USA.
Katherine E PhillipsDepartment of Psychology, Temple University, Philadelphia, PA, USA.
Golda S GinsburgDepartment of Psychiatry, University of Connecticut School of Medicine, West Harford, CT, USA.
Courtney KeetonDivision of Child & Adolescent Psychiatry, Johns Hopkins, Baltimore, MD, USA.
Anne Marie AlbanoDepartment of Psychiatry, Columbia University, New York, NY, USA.
John PiacentiniDepartment of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA.
Tara PerisDepartment of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA, USA.
Scott ComptonDepartment of Psychiatry and Behavioral Sciences, Duke University, Durham, NC, USA.
Dara SakolskyDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Boris BirmaherDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Philip C KendallDepartment of Psychology, Temple University, Philadelphia, PA, USA.
Temple University · USJohns Hopkins University · USNeurobehavioral Systems · USUniversity of Pittsburgh · USColumbia University · USDuke University · USKennedy Krieger Institute · USUniversity of Connecticut · US

Funding

TRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064089 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GINSBURG, GOLDA SUSAN · 2002 to 2007
$3.1M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064003 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS · 2002 to 2007
$2.7M
Child and Adolescent Anxiety Multisite Study (CAMS)U01MH064107 · NIMH · DUKE UNIVERSITY · PI MARCH, JOHN S · 2002 to 2007
$2.4M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH063747 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI KENDALL, PHILIP C · 2002 to 2007
$2.2M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064088 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIACENTINI, JOHN C. · 2002 to 2007
$2.1M
5/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064107 · NIMH · DUKE UNIVERSITY · PI COMPTON, SCOTT N · 2010 to 2014
$1.3M
3/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064089 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GINSBURG, GOLDA SUSAN, KEETON, COURTNEY PIERCE · 2010 to 2014
$925k
2/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064003 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SAKOLSKY, DARA JENNIFER · 2010 to 2014
$659k
4/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH063747 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI KENDALL, PHILIP C · 2010 to 2014
$618k
6/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064088 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIACENTINI, JOHN C. · 2010 to 2014
$611k
1/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064092 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALBANO, ANNE MARIE · 2010 to 2014
$574k
NIMH NIH HHS F31 MH123038NIMH NIH HHS F31 MH124346NIMH NIH HHS R01 MH063747NIMH NIH HHS R01 MH064003NIMH NIH HHS R01 MH064088NIMH NIH HHS R01 MH064089NIMH NIH HHS R01 MH064092NIMH NIH HHS R01 MH064107NIMH NIH HHS T32 MH073517NIMH NIH HHS U01 MH063747NIMH NIH HHS U01 MH064003NIMH NIH HHS U01 MH064088NIMH NIH HHS U01 MH064089NIMH NIH HHS U01 MH064107
6 · The paper itself

Abstract

The current study explored whether patient characteristics predicted patterns of antidepressant use (i.e., never used, single episode of use, or two or more episodes) in a naturalistic follow-up. Participants in the child/adolescent multimodal (CAMS) extended long-term study. (n = 318) indicated medication use over the course of eight follow-up visits, 3-12 years after receiving treatment in CAMS. 40.6% of participants reported never using an antidepressant during follow-up, 41.4% reported a single episode of antidepressant use, and 18.0% reported multiple episodes of antidepressant use. Greater baseline anxiety severity marginally predicted a single episode of antidepressant use; baseline depression severity predicted multiple episodes of use. Reasons for discontinuing antidepressants included perceived ineffectiveness (31.8%), side effects (25.5%), and improvement in symptoms (18.5%). Exploratory analyses examined predictors of medication use. Findings suggest that antidepressant use is common among anxious youth, as is discontinuation of antidepressant use. Clinical implications and future directions are discussed.

Indexed as

AdolescentAdultAntidepressive AgentsAnxietyAnxiety DisordersChildDepressive DisorderFollow-Up StudiesHumansLongitudinal StudiesMaleYoung AdultAntidepressive AgentsAntidepressantAnxietyLongitudinalTreatment

Identifiers

PMID32253545
PMCPMC7541463
OpenAlexW3014444049

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.