Trial reportPediatric nephrology (Berlin, Germany)2020
Home-based inspiratory muscle training in pediatric patients after kidney transplantation: a randomized clinical trial.
Trial report in Pediatric nephrology (Berlin, Germany), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 8 citations in OpenAlex.
- Telerehabilitation exercise program in pediatric patients after kidney transplantation: a randomized clinical trial.Pediatric nephrology (Berlin, Germany) · 2026Trial
- Physical activity among children and young people with chronic kidney diseases: a scoping review.Pediatric nephrology (Berlin, Germany) · 2026Article
- Feasibility and acceptability of a telehealth-supported physical activity program for children with chronic kidney disease: a pilot mixed methods study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Effect of inspiratory muscle training on fatigue, aerobic capacity, pulmonary functions, and quality of life in adolescents with familial Mediterranean fever: a randomized controlled trial.Irish journal of medical science · 2026Article
- Effects of combined inspiratory and expiratory muscle training in pediatric kidney transplant recipients: a randomized controlled study.Pediatric nephrology (Berlin, Germany) · 2026Article
- Improvement of IL-4, IL-6, IL-10, TNF-α and IFN-γ in children with mycoplasma pneumonia through the combination of video scenario-based breathing training and antibiotics.Sleep & breathing = Schlaf & Atmung · 2025Article
- Physical performance capacity after pediatric kidney transplant and clinical parameters associated with physical performance capacity.Pediatric nephrology (Berlin, Germany) · 2023Article
- Physical activity and the 'pediatric inactivity triad' in children living with chronic kidney disease: a narrative review.Therapeutic advances in chronic disease · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease (CKD) represents the irreversible stages of renal failure and is a growing worldwide public health issue associated with increases in morbidity, mortality, and decreased quality of life. Kidney transplantation is considered one of the best treatment options in this population. However, even after surgery, respiratory muscle strength is below normal values, and inspiratory muscle training (IMT) improves respiratory muscle function, strength, and endurance. This study aimed to evaluate the effects of IMT regarding respiratory muscle strength, functional capacity, and pulmonary function in pediatric kidney transplant recipients with CKD, and secondarily, to assess the biochemical profile of patients after intervention.
methodsThis is a randomized, double-blind, placebo-controlled trial. Patients were randomized into two groups, intervention (IG) and control (CG) and performed IMT home-based training for 6 weeks. In the IG, the load was adjusted to 40% of the maximal inspiratory pressure and in the CG was adjusted to a minimum placebo load (9 cm H
resultsThirty-one patients were randomly allocated to the intervention (n = 16) or control (n = 15) groups. There were no differences at baseline between groups. Increase of 35% in the maximal inspiratory pressure predicted and 26% in the maximal expiratory pressure predicted in the IG were found, compared with 5 and 4% in the CG. There was an increase in hemoglobin and hematocrit values in the IG.
conclusionsHome-based IMT provides a significant increase in respiratory muscle strength, without changes in functional capacity and pulmonary function. Benefits regarding biochemical markers (hemoglobin and hematocrit) were also observed.
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