Evidence map›Paper›PMID 32253508›Full record

ArticleJournal of neurology2020

Diaphragmatic CMAP amplitude from phrenic nerve stimulation predicts functional decline in ALS.

Bruno Miranda, Marta Gromicho, Mariana Pereira, Susana Pinto, Michael Swash, Mamede de Carvalho

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. The difference in the diaphragmatic physiological measures between inspiratory and expiratory phases in ALS.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

Bruno MirandaDepartment of Neurosciences and Mental Health, Hospital de Santa Maria-CHLN, Lisbon, Portugal. bruno.a.miranda@gmail.com.ORCID http://orcid.org/0000-0003-4660-6051
Marta GromichoFaculdade de Medicina, Instituto de Medicina Molecular, Translational Clinical Physiology, Universidade de Lisboa, Lisbon, Portugal.ORCID http://orcid.org/0000-0003-2111-4579
Mariana PereiraFaculdade de Medicina, Instituto de Medicina Molecular, Translational Clinical Physiology, Universidade de Lisboa, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-1574-6476
Susana PintoFaculdade de Medicina, Instituto de Medicina Molecular, Translational Clinical Physiology, Universidade de Lisboa, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-0727-5897
Michael SwashFaculdade de Medicina, Instituto de Medicina Molecular, Translational Clinical Physiology, Universidade de Lisboa, Lisbon, Portugal.ORCID http://orcid.org/0000-0002-8717-8914
Mamede de CarvalhoDepartment of Neurosciences and Mental Health, Hospital de Santa Maria-CHLN, Lisbon, Portugal.ORCID http://orcid.org/0000-0001-7556-0158
University of Lisbon · PT

Funding

Fundação para a Ciência e a Tecnologia PTDC/MEC-NEU/31195/2017Santa Casa da Misericórdia de Lisboa Prémio João Lobo Antunes 2017
6 · The paper itself

Abstract

objectiveTo evaluate phrenic nerve motor amplitude (PhrenicAmp) as an independent predictor of functional decline in amyotrophic lateral sclerosis (ALS). We also assessed both PhrenicAmp and forced vital capacity (FVC) as predictors of functional loss in patients with bulbar dysfunction.

methodsWe included consecutive ALS patients with PhrenicAmp and FVC at baseline. Participants were evaluated with the revised ALS Functional Rating Scale (ALSFRS-R) at inclusion and at, at least, one subsequent follow-up visit. The outcome measure of functional decline was the percentage reduction in ALSFRS-R from baseline. Bulbar dysfunction was defined by the presence of any relevant symptom on the ALSFRS-R bulbar sub-score. Correlations and mixed-effects regressions were used to study the relationship between functional decline and both PhrenicAmp and FVC baseline evaluations.

resultsA total of 249 ALS patients were included; 64.2% of these had bulbar dysfunction. At inclusion, significant correlations were found between PhrenicAmp and FVC (p < 0.001), as well as between each respiratory measure and ALSFRS-R (all p < 0.001). The functional decline at first (median 3 months) and second (median 6 months) follow-up visits was significantly correlated with baseline values of both respiratory evaluations (all p < 0.01) in the entire ALS population, but only with baseline PhrenicAmp (all p < 0.05) in bulbar dysfunction cases. Regression analysis revealed that PhrenicAmp (all p < 0.05), but not FVC, was a significant independent predictor of functional decline in ALS patients and in those with bulbar dysfunction.

conclusionBaseline PhrenicAmp is an independent predictor of functional decline in ALS, whether or not bulbar dysfunction is present.

Indexed as

Disease ProgressionAction PotentialsAgedAmyotrophic Lateral SclerosisDeglutition DisordersDiaphragmElectric StimulationFemaleFollow-Up StudiesHumansMaleMiddle AgedPhrenic NerveSalivary Gland DiseasesSpeech DisordersVital CapacityAmyotrophic lateral sclerosisDiaphragmForced vital capacityFunctional declinePhrenic nerve motor response

Identifiers

PMID32253508
OpenAlexW3014500394

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.