ArticleScandinavian journal of work, environment & health2020
Association between asbestos exposure and pericardial and tunica vaginalis testis malignant mesothelioma: a case-control study and epidemiological remarks.
Article in Scandinavian journal of work, environment & health, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 31 citations in OpenAlex.
- Prognostic Factors and Survival in Pericardial Mesothelioma: A Systematic Review and Quantitative Analysis.Cancers · 2026Review
- Efficacy of Nivolumab in Chemotherapy-Resistant Mesothelioma of the Tunica Vaginalis Testis: A Case Report.Cancer reports (Hoboken, N.J.) · 2026Article
- Case Report: Tislelizumab combined with bevacizumab in the treatment of primary malignant pericardial mesothelioma.Frontiers in oncology · 2026Article
- Peritoneal mesothelioma and asbestos exposure: a population-based case-control study in Italy, 2000-2021.Occupational and environmental medicine · 2025Article
- Pericardial Mesothelioma: Diagnostic and Therapeutic Management, a Population-Based Study in Italy.Cancers · 2025Article
- Diagnostic and Therapeutic Management of Mesothelioma of the Tunica Vaginalis Testis: A Population-Based Study in Italy.Cancers · 2025Article
- Primary Malignant Mesothelioma of the Tunica Vaginalis: A Case Report and Review of the Literature.Cureus · 2025Article
- Mesothelioma of the Tunica Vaginalis Testis: Diagnostic and Therapeutic Management. A Comprehensive Review, 1982-2024.Cancers · 2024Review
- Five decades of occupational cancer epidemiology.Scandinavian journal of work, environment & health · 2024Review
- Asbestos ban policies and mesothelioma mortality in Greece.BMC public health · 2024Article
- Article
- Testicular mesothelioma disguised as hydrocele: a case report.Journal of medical case reports · 2024Article
- Pericardial mesothelioma mimicking mediastinal lymphoma and systemic rheumatic disease: a case report.Frontiers in oncology · 2024Article
- Case Report: A case of primary pericardial mesothelioma treated with multimodal combined therapy.Frontiers in cardiovascular medicine · 2024Article
- Recurrent Tumor Suppressor Alterations in Primary Pericardial Mesothelioma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2023Article
- Pleural mesothelioma risk in the construction industry: a case-control study in Italy, 2000-2018.BMJ open · 2023Article
- Are cleaning activities a source of exposure to crystalline silica in women with rheumatoid arthritis? A case-control study.RMD open · 2023Article
- Asbestos exposure as an additional risk factor for small duct intrahepatic cholangiocarcinoma: a pilot study.Scientific reports · 2023Article
- The Italian Experience in the Development of Mesothelioma Registries: A Pathway for Other Countries to Address the Negative Legacy of Asbestos.International journal of environmental research and public health · 2023Article
- Case Report: Early diagnosis and bevacizumab-based chemotherapy for primary pericardial mesothelioma: a case with occupational asbestos exposure history.Frontiers in cardiovascular medicine · 2023Article
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Authors and funding
27 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objectives The purposes of this study are to describe the epidemiology of pericardial and tunica vaginalis testis mesothelioma and assess the role of asbestos exposure for these rare diseases. Methods Based on incident pericardial and tunica vaginalis testis mesothelioma cases collected from the Italian national mesothelioma registry (ReNaM) in the period 1993-2015, incidence rates, survival median period and prognostic factors have been evaluated. A case-control study has been performed to analyze the association with asbestos exposure (occupational and non-occupational) for these diseases. Results Between 1993 and 2015, 58 pericardial (20 women and 38 men) and 80 tunica vaginalis testis mesothelioma cases have been registered with a mean annual standardized (world standard population as reference) incidence rates of 0.049 (per million) in men and 0.023 in women for the pericardial site, and 0.095 for tunica vaginalis testis mesothelioma. Occupational exposure to asbestos was significantly associated with the risk of the diseases [odds ratio (OR) 3.68, 95% confidence interval (CI) 1.85-7.31 and OR 3.42, 95% CI 1.93-6.04 in pericardial and tunica vaginalis testis mesothelioma, respectively]. The median survival was 2.5 months for pericardial and 33.0 months for tunica vaginalis testis mesotheliomas. Age was the main predictive factor for survival for both anatomical sites. Conclusions For the first time in an analytical study, asbestos exposure was associated with pericardial and tunica vaginalis testis mesothelioma risk, supporting the causal role of asbestos for all anatomical sites. The extreme rarity of the diseases, the poor survival and the prognostic role of age have been confirmed based on population and nationwide mesothelioma registry data.
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