ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020
A Causal Role for Mouse Superior Colliculus in Visual Perceptual Decision-Making.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Somatosensory cortex shapes perceptual decision bias via the superior colliculus.Research square · 2026Article
- An inhibitory brainstem pathway reduces visual detection during background motion.Nature communications · 2026Article
- A Distinct Circuit for Biasing Visual Perceptual Decisions and Modulating Superior Colliculus Activity through the Mouse Posterior Striatum.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neuronal Features of Visual Attention in the Mouse Superior Colliculus Depend on Learned Behavioral Relevance.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Investigating mouse superior colliculus function using two-photon calcium imaging.Frontiers in cellular neuroscience · 2026Review
- Superior Colliculus Projections Drive Dopamine Neuron Activity and Movement But Not Value.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Fundamental role of brain-organ interaction in behavior-driven holistic homeostasis.Fundamental research · 2025Review
- Functional specialisation of multisensory temporal integration in the mouse superior colliculus.Nature communications · 2025Article
- Map of spiking activity underlying change detection in the mouse visual system.bioRxiv : the preprint server for biology · 2025Article
- Superior colliculus encodes the visual cue associated with rewarding behavior in sucrose self-administration in mice.Scientific reports · 2025Article
- Superior colliculus projections drive dopamine neuron activity and movement but not value.bioRxiv : the preprint server for biology · 2025Article
- A distinct circuit for biasing visual perceptual decisions and modulating superior colliculus activity through the mouse posterior striatum.bioRxiv : the preprint server for biology · 2025Article
- Effort drives saccade selection.eLife · 2025Article
- Stimulus selection enhances value-modulated somatosensory processing in the superior colliculus.PLoS biology · 2025Article
- Optogenetic Manipulation of Covert Attention in the Nonhuman Primate.Journal of cognitive neuroscience · 2025Article
- Genetically defined neuron types underlying visuomotor transformation in the superior colliculus.Nature reviews. Neuroscience · 2024Review
- Stimulus-dependent differences in cortical versus subcortical contributions to visual detection in mice.Current biology : CB · 2024Article
- The influence of cortical activity on perception depends on behavioral state and sensory context.Nature communications · 2024Article
- Article
- Reward Modulates Visual Responses in the Superficial Superior Colliculus of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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5 authors.
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Abstract
The superior colliculus (SC) is arguably the most important visual structure in the mouse brain and is well known for its involvement in innate responses to visual threats and prey items. In other species, the SC plays a central role in voluntary as well as innate visual functions, including crucial contributions to selective attention and perceptual decision-making. In the mouse, the possible role of the SC in voluntary visual choice behaviors has not been established. Here, we demonstrate that the mouse SC of both sexes plays a causal role in visual perceptual decision-making by transiently inhibiting SC activity during an orientation change detection task. First, unilateral SC inhibition-induced spatially specific deficits in detection. Hit rates were reduced, and reaction times increased for orientation changes in the contralateral but not ipsilateral visual field. Second, the deficits caused by SC inhibition were specific to a temporal epoch coincident with early visual burst responses in the SC. Inhibiting SC during this 100-ms period caused a contralateral detection deficit, whereas inhibition immediately before or after did not. Third, SC inhibition reduced visual detection sensitivity. Psychometric analysis revealed that inhibiting SC visual activity significantly increased detection thresholds for contralateral orientation changes. In addition, effects on detection thresholds and lapse rates caused by SC inhibition were larger in the presence of a competing visual stimulus, indicating a role for the mouse SC in visual target selection. Together, our results demonstrate that the mouse SC is necessary for the normal performance of voluntary visual choice behaviors.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.