Evidence map›Paper›PMID 32253235›Full record

ArticleThe Journal of biological chemistry2020

Mutations in penicillin-binding protein 2 from cephalosporin-resistant

Avinash Singh, Jonathan M Turner, Joshua Tomberg, Alena Fedarovich, Magnus Unemo, Robert A Nicholas, Christopher Davies

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
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  6. Clonal Expansion ofInfection and drug resistance · 2026
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  13. Rolling the evolutionary dice:Microbiology spectrum · 2024
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  16. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Avinash SinghDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425.
Jonathan M TurnerDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425.
Joshua TombergDepartments of Pharmacology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599.
Alena FedarovichDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425.
Magnus UnemoWHO Collaborating Centre for Gonorrhoea and other STIs, Department of Laboratory Medicine, Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Robert A NicholasDepartments of Pharmacology and Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599. Electronic address: nicholas@med.unc.edu.
Christopher DaviesDepartment of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425. Electronic address: davies@musc.edu.
Medical University of South Carolina · USUniversity of North Carolina at Chapel Hill · USÖrebro University · SE

Funding

The Atlantic Coast Sexually Transmitted Infection Cooperative Research Center (ACU19AI113170 · NIAID · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI JERSE, ANN E. · 2014 to 2018
$6.9M
Supplement to Molecular Targets in Peptidoglycan SynthesisR01GM066861 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DAVIES, CHRISTOPHER · 2003 to 2019
$5.4M
Crystallization robotics to support X-ray crystallography at MUSCS10RR027139 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI DAVIES, CHRISTOPHER · 2011 to 2011
$125k
NCRR NIH HHS S10 RR027139NIAID NIH HHS U19 AI113170NIGMS NIH HHS R01 GM066861
6 · The paper itself

Abstract

The global incidence of the sexually transmitted disease gonorrhea is expected to rise due to the spread of

Indexed as

Cephalosporin ResistanceAcetylationAmino Acid SubstitutionBacterial ProteinsCeftriaxoneMutation, MissenseNeisseria gonorrhoeaeProtein Structure, SecondarySerine-Type D-Ala-D-Ala CarboxypeptidaseBacterial ProteinsCeftriaxonepenicillin-binding protein 2, Neisseria gonorrhoeaeSerine-Type D-Ala-D-Ala Carboxypeptidaseantibiotic resistanceceftriaxoneconformational changeextended-spectrum cephalosporinsNeisseria gonorrhoeaeoxyanion holepenicillin-binding proteinpeptidoglycanprotein dynamicX-ray crystallography

Identifiers

PMID32253235
PMCPMC7247294
OpenAlexW3014722732

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.