ArticleAntimicrobial agents and chemotherapy2020
Structural Recognition of Spectinomycin by Resistance Enzyme ANT(9) from Enterococcus faecalis.
Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 27 citations in OpenAlex.
- Discovery and characterization of a novel chromosomally encoded aminoglycosideFrontiers in cellular and infection microbiology · 2026Article
- Cloning and molecular characterization ofFrontiers in microbiology · 2026Article
- Comparison of Phenotypic and Whole-Genome Sequencing-Derived Antimicrobial Resistance Profiles ofAntibiotics (Basel, Switzerland) · 2025Article
- DeepSEA: an alignment-free explainable approach to annotate antimicrobial resistance proteins.BMC bioinformatics · 2025Article
- A modified BPaL regimen for tuberculosis treatment replaces linezolid with inhaled spectinamides.eLife · 2024Article
- Non-Clinical microbiology reviews · 2024Review
- Validation of the method for determining lincomycin levels and calculating lincomycin levels in broiler chicken plasma using high-performance liquid chromatography.Open veterinary journal · 2024Article
- ANT(9)-Ic, a Novel Chromosomally Encoded Aminoglycoside Nucleotidyltransferase from Brucella intermedia.Microbiology spectrum · 2023Article
- AadA36, a novel chromosomal aminoglycoside nucleotidyltransferase from a clinical isolate ofFrontiers in microbiology · 2022Article
- Identification of a novel aminoglycosideFrontiers in microbiology · 2022Article
- Synthesis, antibacterial action, and ribosome inhibition of deoxyspectinomycins.The Journal of antibiotics · 2021Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spectinomycin is a ribosome-binding antibiotic that blocks the translocation step of translation. A prevalent resistance mechanism is modification of the drug by aminoglycoside nucleotidyl transferase (ANT) enzymes of the spectinomycin-specific ANT(9) family or by enzymes of the dual-specificity ANT(3")(9) family, which also acts on streptomycin. We previously reported the structural mechanism of streptomycin modification by the ANT(3")(9) AadA from
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