Evidence map›Paper›PMID 32253208›Full record

ArticleAntimicrobial agents and chemotherapy2020

Development of Probiotic Formulations for Oral Candidiasis Prevention: Gellan Gum as a Carrier To Deliver Lactobacillus paracasei 28.4.

Felipe de Camargo Ribeiro, Juliana Campos Junqueira, Jéssica Diane Dos Santos, Patrícia Pimentel de Barros, Rodnei Dennis Rossoni, Shashank Shukla, Beth Burgwyn Fuchs, Anita Shukla, Eleftherios Mylonakis

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05107622 (Administration of L. Paracasei 28.4 as an Adjunct to the Treatment of Periodontitis), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05107622 phase1 / phase2unknown statusnot on this mapstarted 2021, after this paper: background citation

Administration of L. Paracasei 28.4 as an Adjunct to the Treatment of Periodontitis: Superiority Placebo-controlled Randomized Clinical Trial

TypeinterventionalSponsorUniversidade Estadual Paulista Júlio de Mesquita FilhoRan2021 to 2024Enrolled60ConditionsPeriodontitisArmsFMUD+Probiotic, FMUD+Placebo
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 37 citations in OpenAlex.

  1. Review
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  8. Review
  9. In Vivo Efficacy ofJournal of fungi (Basel, Switzerland) · 2021
    Article
  10. Article
  11. The Anti-Biofilm Efficacy of Caffeic Acid Phenethyl Ester (CAPE)Frontiers in cellular and infection microbiology · 2021
    Article
  12. Frontiers in microbiology · 2020
    Article
  13. The Postbiotic Activity ofFrontiers in cellular and infection microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Felipe de Camargo RibeiroDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University/UNESP, São José dos Campos, São Paulo, Brazil.ORCID 0000-0003-3677-3243
Juliana Campos JunqueiraDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University/UNESP, São José dos Campos, São Paulo, Brazil juliana.junqueira@unesp.br.
Jéssica Diane Dos SantosDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University/UNESP, São José dos Campos, São Paulo, Brazil.
Patrícia Pimentel de BarrosDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University/UNESP, São José dos Campos, São Paulo, Brazil.
Rodnei Dennis RossoniDepartment of Biosciences and Oral Diagnosis, Institute of Science and Technology, São Paulo State University/UNESP, São José dos Campos, São Paulo, Brazil.
Shashank ShuklaSchool of Engineering, Brown University, Providence, Rhode Island, USA.
Beth Burgwyn FuchsDivision of Infectious Disease, Alpert Medical School, Brown University, Providence, Rhode Island, USA.
Anita ShuklaSchool of Engineering, Brown University, Providence, Rhode Island, USA.
Eleftherios MylonakisDivision of Infectious Disease, Alpert Medical School, Brown University, Providence, Rhode Island, USA.ORCID 0000-0002-4624-0777
Universidade Estadual Paulista (Unesp) · BRBrown University · US

Funding

Training CoreP20GM103430 · NIGMS · UNIVERSITY OF RHODE ISLAND · PI Bongsup P Cho · 2012 to 2026
$63.6M
NIGMS NIH HHS P20 GM103430
6 · The paper itself

Abstract

Probiotics might provide an alternative approach for the control of oral candidiasis. However, studies on the antifungal activity of probiotics in the oral cavity are based on the consumption of yogurt or other dietary products, and it is necessary to use appropriate biomaterials and specific strains to obtain probiotic formulations targeted for local oral administration. In this study, we impregnated gellan gum, a natural biopolymer used as a food additive, with a probiotic and investigated its antifungal activity against

Indexed as

Candidiasis, OralLacticaseibacillus paracaseiProbioticsAnimalsMicePolysaccharides, Bacterialgellan gumPolysaccharides, BacterialCandida albicansgellan gumhydrogelsLactobacillus paracaseioral candidiasis

Identifiers

PMID32253208
PMCPMC7269487
OpenAlexW3014375962

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.