ArticleJournal of geriatric oncology2020
Prognostic nutritional index (PNI), independent of frailty is associated with six-month postoperative mortality.
Article in Journal of geriatric oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Association of prognostic nutritional index with risk of contrast induced nephropathy: A meta-analysis.Frontiers in nutrition · 2023Pooled it
- Association of polypharmacy and perioperative outcomes: Systematic review and meta-analysis.Journal of perioperative practicePooled it
- An L-shaped association between prognostic nutritional index and all-cause mortality among adults with depressive symptoms: a cohort study using NHANES 2005-2018.BMC psychiatry · 2026Article
- Article
- Intrapleural Gentian Violet Irrigation for Refractory Methicillin-ResistantRespirology case reports · 2026Article
- Article
- Prognostic nutritional index at admission predicts 90-day mortality in patients aged ≥80 years with hip fracture: a system-level readout of the nutrition-immune milieu relevant to microenvironment-responsive bone repair.Frontiers in medicine · 2026Article
- Routine laboratory composite indices and geriatric multisyndrome burden: a head to head evaluation against serum albumin.Frontiers in medicine · 2026Article
- Article
- Construction of a predictive model for concurrent infection in liver failure patients based on prognostic nutritional index and inflammatory cytokine analysis.BMC gastroenterology · 2025Article
- Association of Prognostic Nutritional Index and Mortality in Older Adults Undergoing Hip Fracture Surgery: A Retrospective Observational Study at a Single Large Center.Medicina (Kaunas, Lithuania) · 2025Observational
- Associations of prognostic nutritional index with cardiovascular all-cause mortality among CVD patients with diabetes or prediabetes: evidence from the NHANES 2005-2018.Frontiers in immunology · 2025Article
- Association between Prognostic Nutritional Index and Mortality Risk in Critically Ill Patients with Chronic Obstructive Pulmonary Disease: A Retrospective Study.International journal of chronic obstructive pulmonary disease · 2025Article
- Incidence and influencing factors of postoperative frailty in elderly prostate cancer patients: a cross-sectional study.Frontiers in medicine · 2025Article
- Immune nutrition indices are associated with disease activity in rheumatoid arthritis: a cross-sectional study.Biomarkers in medicine · 2024Article
- Assessing the predictive power of nutritional indices on all-cause and cardiovascular mortality in hemodialysis patients: a longitudinal study.Renal failure · 2024Article
- Association between prognostic nutritional index and mortality risk in patients with community-acquired pneumonia: a retrospective study.BMC pulmonary medicine · 2024Article
- Nomogram predicting the prognosis of primary liver cancer after radiofrequency ablation combined with transcatheter arterial chemoembolization.World journal of gastrointestinal surgery · 2024Article
- Phenotypes of patients with systemic sclerosis in the Chinese Han population: a cluster analysis.Clinical rheumatology · 2024Article
- Observational
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
introductionPrognostic Nutritional Index (PNI) is associated with disease and overall survival in patients with cancer. We aimed to assess the relationship between PNI, frailty, and six-month postoperative survival in older patients with cancer.
methodsIn this retrospective study, patients with cancer aged ≥75 who underwent geriatric preoperative evaluation and then proceeded with elective surgery with hospital length of stay of ≥1 day and had six-month follow-up were included. PNI is measured by preoperative [10 × albumin(gr/dl)] + [0.005 × absolute lymphocyte count (per mm
resultsPNI ranged from 19 to 49 (average 40) among 1025 patients (average age 80). Patients with impairment in Karnofsky Performance Status, falls in the past year, prolonged timed up and go test, limited social activity, significant weight loss, polypharmacy, polycomorbid conditions, depression, and dependent for basic and instrumental activities of daily living had lower PNI than fit patients. The correlation coefficient between PNI and number of aging impairments was -0.28 (p < .001). Each unit increase in PNI was associated with 10% reduction in 6-month mortality (OR = 0.90, p < .001).
conclusionPNI independent of frailty, age, American Society of Anesthesiologist Performance Scale (ASA-PS), and metastatic disease is associated with six-month postoperative mortality. Future studies should assess the interventions aimed at improving PNI and its impact on surgical outcomes.
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